Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Shim, Do-Wan | - |
dc.contributor.author | Shin, Hee Jae | - |
dc.contributor.author | Han, Ji-Won | - |
dc.contributor.author | Shin, Woo-Young | - |
dc.contributor.author | Sun, Xiao | - |
dc.contributor.author | Shim, Eun-Jeong | - |
dc.contributor.author | Kim, Tack-Joong | - |
dc.contributor.author | Kang, Tae-Bong | - |
dc.contributor.author | Lee, Kwang-Ho | - |
dc.date.accessioned | 2020-04-20T03:40:37Z | - |
dc.date.available | 2020-04-20T03:40:37Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/2509 | - |
dc.description.abstract | Streptochlorin, a small compound derived from marine actinomycete, has been shown to have anti-angiogenic, anti-tumor, and anti-allergic activities. However, the anti-inflammatory effects and underlying mechanisms have not yet been reported. In the present study, we investigated the effect of streptochlorin on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. Streptochlorin attenuated the production of proinflammatory mediators such as nitric oxide, cyclooxygenase-2, pro-interleukin (IL)-1, and IL-6 in LPS-stimulated RAW264.7 cells through inhibition of the Toll/interleukin-1 receptor (TIR)-domain-containing adapter-inducing interferon- (TRIF)-dependent signaling pathway. Furthermore, streptochlorin suppressed the infiltration of immune cells such as neutrophils into the lung and proinflammatory cytokine production such as IL-6 and TNF- in broncho-alveolar lavage fluid (BALF) in the LPS-induced acute lung injury (ALI) mouse model. Streptochlorin has potent anti-inflammatory effects through regulating TRIF-dependent signaling pathways, suggesting that streptochlorin may provide a valuable therapeutic strategy in treating various inflammatory diseases. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.title | Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models | - |
dc.type | Article | - |
dc.citation.endPage | 6910 | - |
dc.citation.startPage | 6902 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 16 | - |
dc.citation.number | 4 | - |
dc.contributor.alternativeName | 신희재 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.16, no.4, pp.6902 - 6910 | - |
dc.identifier.doi | 10.3390/ijms16046902 | - |
dc.identifier.scopusid | 2-s2.0-84927651499 | - |
dc.identifier.wosid | 000354040400017 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | ACUTE LUNG INJURY | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordAuthor | streptochlorin | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | TRIF | - |
dc.subject.keywordAuthor | ALI | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |