Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp.
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Title
- Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp.
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Author(s)
- Shin, H.J.; Rashid, M.A.; Cartner, L.K.; Bokesch, H.R.; Wilson, J.A.; McMahon, J.B.; Gustafson, K.R.
- KIOST Author(s)
- Shin, Hee Jae(신희재)
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Alternative Author(s)
- 신희재
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Publication Year
- 2015-06
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Abstract
- Two new HIV-inhibitory depsipeptides, stellettapeptins A (1) and B (2), were isolated from an extract of the marine sponge Stelletta sp., collected from northwestern Australia. Structures of these cyclic nonribosomal peptides were elucidated on the basis of extensive NMR data analysis, and chemical degradation and derivatization studies. Stellettapeptins contain numerous nonproteinogenic amino acid residues and they are the first peptides reported to contain a 3-hydroxy-6,8-dimethylnon-4-(Z)-enoic acid moiety. Compounds 1 and 2 potently inhibit infection of human T-lymphoblastoid cells by HIV-1RF with EC50 values of 23 and 27 nM, respectively.
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ISSN
- 0040-4039
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2469
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DOI
- 10.1016/j.tetlet.2015.05.058
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Bibliographic Citation
- Tetrahedron Letters, v.56, no.28, pp.4215 - 4219, 2015
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Publisher
- Elsevier Ltd
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Keywords
- Anti-HIV; Depsipeptide; Sponge peptide; Stelletta
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Type
- Article
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Language
- English
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Document Type
- Article
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