Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp. SCIE SCOPUS

Cited 11 time in WEB OF SCIENCE Cited 11 time in Scopus
Title
Stellettapeptins A and B, HIV-inhibitory cyclic depsipeptides from the marine sponge Stelletta sp.
Author(s)
Shin, H.J.; Rashid, M.A.; Cartner, L.K.; Bokesch, H.R.; Wilson, J.A.; McMahon, J.B.; Gustafson, K.R.
Publication Year
2015-06
Abstract
Two new HIV-inhibitory depsipeptides, stellettapeptins A (1) and B (2), were isolated from an extract of the marine sponge Stelletta sp., collected from northwestern Australia. Structures of these cyclic nonribosomal peptides were elucidated on the basis of extensive NMR data analysis, and chemical degradation and derivatization studies. Stellettapeptins contain numerous nonproteinogenic amino acid residues and they are the first peptides reported to contain a 3-hydroxy-6,8-dimethylnon-4-(Z)-enoic acid moiety. Compounds 1 and 2 potently inhibit infection of human T-lymphoblastoid cells by HIV-1RF with EC50 values of 23 and 27 nM, respectively.
ISSN
0040-4039
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2469
DOI
10.1016/j.tetlet.2015.05.058
Bibliographic Citation
Tetrahedron Letters, v.56, no.28, pp.4215 - 4219, 2015
Publisher
Elsevier Ltd
Keywords
Anti-HIV; Depsipeptide; Sponge peptide; Stelletta
Type
Article
Language
English
Document Type
Article
Publisher
Elsevier Ltd
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