A New Inhibitor of Microglial Neurotoxicity from Marine-Derived Streptomyces sp.
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Title
- A New Inhibitor of Microglial Neurotoxicity from Marine-Derived Streptomyces sp.
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Author(s)
- 신희재; 최병규; 김병욱; 최동국; 이희승; 이종석; 이연주; 이지훈
- KIOST Author(s)
- Shin, Hee Jae(신희재); Lee, Hyi Seung(이희승); Lee, Jong Seok(이종석); Lee, Yeon Ju(이연주); Lee, Ji Hoon(이지훈)
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Alternative Author(s)
- 신희재; 최병규; 이희승; 이종석; 이연주; 이지훈
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Publication Year
- 2016-07-26
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Abstract
- Inflammation in the brain and the rest of the central nervous system (CNS) is a key factor in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Multiple lines of evidence suggest that microglia, the resident immune cells of the CNS, play a critical role in inflammation-mediated neurodegeneration. Microglial cells play a dual role in the central nervous system as they have both neurotoxic and neuroprotective effects. Uncontrolled and excessive activation of microglia often contributes to inflammation-mediated neurodegeneration. As part of our continuing interest to discover secondary metabolites from marine microorganisms, we could isolate a new echinosporin derivative from marine Streptomyces sp., possessing strong anti-neuroinflammatory activity as demonstrated by a reduction in nitric oxide (NO) production in LPS-activated BV-2 microglial cells. The structure of the active compound was determined by extensive NMR and mass spectroscopic studies. An unambiguous assignment of the absolute configuration was also achieved by a single-crystal X-ray diffraction (XRD) experiment.immune cells of the CNS, play a critical role in inflammation-mediated neurodegeneration. Microglial cells play a dual role in the central nervous system as they have both neurotoxic and neuroprotective effects. Uncontrolled and excessive activation of microglia often contributes to inflammation-mediated neurodegeneration. As part of our continuing interest to discover secondary metabolites from marine microorganisms, we could isolate a new echinosporin derivative from marine Streptomyces sp., possessing strong anti-neuroinflammatory activity as demonstrated by a reduction in nitric oxide (NO) production in LPS-activated BV-2 microglial cells. The structure of the active compound was determined by extensive NMR and mass spectroscopic studies. An unambiguous assignment of the absolute configuration was also achieved by a single-crystal X-ray diffraction (XRD) experiment.
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/24650
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Bibliographic Citation
- International Conference and Exhibition on Marine Drugs and Natural Products, pp.80, 2016
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Publisher
- conferenceseries.com
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Type
- Conference
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Language
- English
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