A New Inhibitor of Microglial Neurotoxicity from Marine-Derived Streptomyces sp.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신희재 | - |
dc.contributor.author | 최병규 | - |
dc.contributor.author | 김병욱 | - |
dc.contributor.author | 최동국 | - |
dc.contributor.author | 이희승 | - |
dc.contributor.author | 이종석 | - |
dc.contributor.author | 이연주 | - |
dc.contributor.author | 이지훈 | - |
dc.date.accessioned | 2020-07-15T20:52:23Z | - |
dc.date.available | 2020-07-15T20:52:23Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2016-07-26 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/24650 | - |
dc.description.abstract | Inflammation in the brain and the rest of the central nervous system (CNS) is a key factor in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Multiple lines of evidence suggest that microglia, the resident immune cells of the CNS, play a critical role in inflammation-mediated neurodegeneration. Microglial cells play a dual role in the central nervous system as they have both neurotoxic and neuroprotective effects. Uncontrolled and excessive activation of microglia often contributes to inflammation-mediated neurodegeneration. As part of our continuing interest to discover secondary metabolites from marine microorganisms, we could isolate a new echinosporin derivative from marine Streptomyces sp., possessing strong anti-neuroinflammatory activity as demonstrated by a reduction in nitric oxide (NO) production in LPS-activated BV-2 microglial cells. The structure of the active compound was determined by extensive NMR and mass spectroscopic studies. An unambiguous assignment of the absolute configuration was also achieved by a single-crystal X-ray diffraction (XRD) experiment.immune cells of the CNS, play a critical role in inflammation-mediated neurodegeneration. Microglial cells play a dual role in the central nervous system as they have both neurotoxic and neuroprotective effects. Uncontrolled and excessive activation of microglia often contributes to inflammation-mediated neurodegeneration. As part of our continuing interest to discover secondary metabolites from marine microorganisms, we could isolate a new echinosporin derivative from marine Streptomyces sp., possessing strong anti-neuroinflammatory activity as demonstrated by a reduction in nitric oxide (NO) production in LPS-activated BV-2 microglial cells. The structure of the active compound was determined by extensive NMR and mass spectroscopic studies. An unambiguous assignment of the absolute configuration was also achieved by a single-crystal X-ray diffraction (XRD) experiment. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | conferenceseries.com | - |
dc.relation.isPartOf | International Conference and Exhibition on Marine Drugs and Natural Products | - |
dc.title | A New Inhibitor of Microglial Neurotoxicity from Marine-Derived Streptomyces sp. | - |
dc.type | Conference | - |
dc.citation.endPage | 80 | - |
dc.citation.startPage | 80 | - |
dc.citation.title | International Conference and Exhibition on Marine Drugs and Natural Products | - |
dc.contributor.alternativeName | 신희재 | - |
dc.contributor.alternativeName | 최병규 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.contributor.alternativeName | 이종석 | - |
dc.contributor.alternativeName | 이연주 | - |
dc.contributor.alternativeName | 이지훈 | - |
dc.identifier.bibliographicCitation | International Conference and Exhibition on Marine Drugs and Natural Products, pp.80 | - |
dc.description.journalClass | 1 | - |