A New Inhibitor of Microglial Neurotoxicity from Marine-Derived Streptomyces sp.

Title
A New Inhibitor of Microglial Neurotoxicity from Marine-Derived Streptomyces sp.
Author(s)
신희재; 최병규; 김병욱; 최동국; 이희승; 이종석; 이연주; 이지훈
KIOST Author(s)
Shin, Hee Jae(신희재)Lee, Hyi Seung(이희승)Lee, Jong Seok(이종석)Lee, Yeon Ju(이연주)Lee, Ji Hoon(이지훈)
Alternative Author(s)
신희재; 최병규; 이희승; 이종석; 이연주; 이지훈
Publication Year
2016-07-26
Abstract
Inflammation in the brain and the rest of the central nervous system (CNS) is a key factor in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Multiple lines of evidence suggest that microglia, the resident immune cells of the CNS, play a critical role in inflammation-mediated neurodegeneration. Microglial cells play a dual role in the central nervous system as they have both neurotoxic and neuroprotective effects. Uncontrolled and excessive activation of microglia often contributes to inflammation-mediated neurodegeneration. As part of our continuing interest to discover secondary metabolites from marine microorganisms, we could isolate a new echinosporin derivative from marine Streptomyces sp., possessing strong anti-neuroinflammatory activity as demonstrated by a reduction in nitric oxide (NO) production in LPS-activated BV-2 microglial cells. The structure of the active compound was determined by extensive NMR and mass spectroscopic studies. An unambiguous assignment of the absolute configuration was also achieved by a single-crystal X-ray diffraction (XRD) experiment.immune cells of the CNS, play a critical role in inflammation-mediated neurodegeneration. Microglial cells play a dual role in the central nervous system as they have both neurotoxic and neuroprotective effects. Uncontrolled and excessive activation of microglia often contributes to inflammation-mediated neurodegeneration. As part of our continuing interest to discover secondary metabolites from marine microorganisms, we could isolate a new echinosporin derivative from marine Streptomyces sp., possessing strong anti-neuroinflammatory activity as demonstrated by a reduction in nitric oxide (NO) production in LPS-activated BV-2 microglial cells. The structure of the active compound was determined by extensive NMR and mass spectroscopic studies. An unambiguous assignment of the absolute configuration was also achieved by a single-crystal X-ray diffraction (XRD) experiment.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/24650
Bibliographic Citation
International Conference and Exhibition on Marine Drugs and Natural Products, pp.80, 2016
Publisher
conferenceseries.com
Type
Conference
Language
English
Publisher
conferenceseries.com
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