New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties SCIE SCOPUS

Cited 3 time in WEB OF SCIENCE Cited 3 time in Scopus
Title
New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties
Author(s)
Ogurtsova, Ekaterina K.; Makarieva, Tatyana N.; Korolkova, Yuliya V.; Andreev, Yaroslav A.; Mosharova, Irina V.; Denisenko, Vladimir A.; Dmitrenok, Pavel S.; Lee, Yeon-Ju; Grishin, Eugene V.; Stonik, Valentin A.
KIOST Author(s)
Lee, Yeon Ju(이연주)
Publication Year
2015-07
Abstract
The guanidine alkaloids, dihydropulchranin A (2), prepared from pulchranin A from the sponge Monanchora pulchra and hexadecylguanidine (3), a synthetic analog of pulchranins, were studied for their TRPV channel-regulating activities. Compound 2 was active as an inhibitor of rTRPV1 and hTRPV3 receptors with EC50 values of 24.3 and 59.1 mu M, respectively. Hexadecylguanidine (3) was not active against these receptors.
ISSN
1934-578X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2450
Bibliographic Citation
NATURAL PRODUCT COMMUNICATIONS, v.10, no.7, pp.1171 - 1173, 2015
Publisher
NATURAL PRODUCTS INC
Subject
SPONGE MONANCHORA-PULCHRA; EASTERN MARINE SPONGE; CHEMISTRY; PRODUCTS; CHANNELS; BIOLOGY
Keywords
Acyclic guanidine alkaloids; Structure-activity relationships; Sponge; Monanchora pulchra; rTRPV1; hTRPV3; rTRPA1
Type
Article
Language
English
Document Type
Article
Publisher
NATURAL PRODUCTS INC
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