New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties SCIE SCOPUS
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- Title
- New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties
- KIOST Author(s)
- Lee, Yeon Ju(이연주)
- Alternative Author(s)
- 이연주
- Publication Year
- 2015-07
- Abstract
- The guanidine alkaloids, dihydropulchranin A (2), prepared from pulchranin A from the sponge Monanchora pulchra and hexadecylguanidine (3), a synthetic analog of pulchranins, were studied for their TRPV channel-regulating activities. Compound 2 was active as an inhibitor of rTRPV1 and hTRPV3 receptors with EC50 values of 24.3 and 59.1 mu M, respectively. Hexadecylguanidine (3) was not active against these receptors.
- ISSN
- 1934-578X
- Bibliographic Citation
- NATURAL PRODUCT COMMUNICATIONS, v.10, no.7, pp.1171 - 1173, 2015
- Publisher
- NATURAL PRODUCTS INC
- Subject
- SPONGE MONANCHORA-PULCHRA; EASTERN MARINE SPONGE; CHEMISTRY; PRODUCTS; CHANNELS; BIOLOGY
- Keywords
- Acyclic guanidine alkaloids; Structure-activity relationships; Sponge; Monanchora pulchra; rTRPV1; hTRPV3; rTRPA1
- Type
- Article
- Language
- English
- Document Type
- Article
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- There are no files associated with this item.
