TuberatolideB의 STAT3 기전을 통하여 ROS의 activation에 의한 세포사멸 효과

Title
TuberatolideB의 STAT3 기전을 통하여 ROS의 activation에 의한 세포사멸 효과
Alternative Title
Induction of apoptotic cell death through activating ROS-Mediated inhibition of STAT3 Signalinf pathway by TuberatolideB
Author(s)
최윤경; 김준성; 예보람; 김민선; 김은아; 허수진
KIOST Author(s)
Kim, Junseong(김준성)Kim, Eun A(김은아)Heo, Soo Jin(허수진)
Publication Year
2017-10-02
Abstract
Cancer still remains a deadly disease and has a high incidence and death rate worldwide. Therefore, targeted cancer therapeutic agents are developed for cancer patients for a long time. Tuberatolide B (C27H34O4) is a diastereomeric meroterpenoid isolated from the Korean marine algae Sargassum macrocarpum. However, the anticancer effects of Tuberatolide B remain unknown. In this study, we demonstrate that Tuberatolide B inhibits tumor growth in breast, lung, colon, prostate, and cervical cancer cells. Tuberatolide B suppressed cancer cell viability (breast cancer, lung cancer, colon cancer, prostate cancer, cervical cancer). In addition, Tuberatolide B did not affect normal monkey kidney epithelial cell viabilities. Tuberatolide B enhanced DNA damage and ROS generation and inhibited STAT3 activation. In addition, TTB-induced ROS generation caused STAT3 inhibition, DNA damage, and apoptotic cell death. Therefore, Tuberatolide B inhibits cancer development by inducing ROS-mediated suppression of STAT3 signaling, suggesting that TTB is useful for the treatment of cancer.enoid isolated from the Korean marine algae Sargassum macrocarpum. However, the anticancer effects of Tuberatolide B remain unknown. In this study, we demonstrate that Tuberatolide B inhibits tumor growth in breast, lung, colon, prostate, and cervical cancer cells. Tuberatolide B suppressed cancer cell viability (breast cancer, lung cancer, colon cancer, prostate cancer, cervical cancer). In addition, Tuberatolide B did not affect normal monkey kidney epithelial cell viabilities. Tuberatolide B enhanced DNA damage and ROS generation and inhibited STAT3 activation. In addition, TTB-induced ROS generation caused STAT3 inhibition, DNA damage, and apoptotic cell death. Therefore, Tuberatolide B inhibits cancer development by inducing ROS-mediated suppression of STAT3 signaling, suggesting that TTB is useful for the treatment of cancer.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/23794
Bibliographic Citation
KSBMB International Concerence 2017, pp.125, 2017
Publisher
KSBMB(생화학생물분자학)
Type
Conference
Language
English
Publisher
KSBMB(생화학생물분자학)
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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