TuberatolideB의 STAT3 기전을 통하여 ROS의 activation에 의한 세포사멸 효과

Abstract

Cancer still remains a deadly disease and has a high incidence and death rate worldwide. Therefore, targeted cancer therapeutic agents are developed for cancer patients for a long time. Tuberatolide B (C27H34O4) is a diastereomeric meroterpenoid isolated from the Korean marine algae Sargassum macrocarpum. However, the anticancer effects of Tuberatolide B remain unknown. In this study, we demonstrate that Tuberatolide B inhibits tumor growth in breast, lung, colon, prostate, and cervical cancer cells. Tuberatolide B suppressed cancer cell viability (breast cancer, lung cancer, colon cancer, prostate cancer, cervical cancer). In addition, Tuberatolide B did not affect normal monkey kidney epithelial cell viabilities. Tuberatolide B enhanced DNA damage and ROS generation and inhibited STAT3 activation. In addition, TTB-induced ROS generation caused STAT3 inhibition, DNA damage, and apoptotic cell death. Therefore, Tuberatolide B inhibits cancer development by inducing ROS-mediated suppression of STAT3 signaling, suggesting that TTB is useful for the treatment of cancer.enoid isolated from the Korean marine algae Sargassum macrocarpum. However, the anticancer effects of Tuberatolide B remain unknown. In this study, we demonstrate that Tuberatolide B inhibits tumor growth in breast, lung, colon, prostate, and cervical cancer cells. Tuberatolide B suppressed cancer cell viability (breast cancer, lung cancer, colon cancer, prostate cancer, cervical cancer). In addition, Tuberatolide B did not affect normal monkey kidney epithelial cell viabilities. Tuberatolide B enhanced DNA damage and ROS generation and inhibited STAT3 activation. In addition, TTB-induced ROS generation caused STAT3 inhibition, DNA damage, and apoptotic cell death. Therefore, Tuberatolide B inhibits cancer development by inducing ROS-mediated suppression of STAT3 signaling, suggesting that TTB is useful for the treatment of cancer.