TuberatolideB의 STAT3 기전을 통하여 ROS의 activation에 의한 세포사멸 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최윤경 | - |
dc.contributor.author | 김준성 | - |
dc.contributor.author | 예보람 | - |
dc.contributor.author | 김민선 | - |
dc.contributor.author | 김은아 | - |
dc.contributor.author | 허수진 | - |
dc.date.accessioned | 2020-07-15T14:34:12Z | - |
dc.date.available | 2020-07-15T14:34:12Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2017-10-02 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/23794 | - |
dc.description.abstract | Cancer still remains a deadly disease and has a high incidence and death rate worldwide. Therefore, targeted cancer therapeutic agents are developed for cancer patients for a long time. Tuberatolide B (C27H34O4) is a diastereomeric meroterpenoid isolated from the Korean marine algae Sargassum macrocarpum. However, the anticancer effects of Tuberatolide B remain unknown. In this study, we demonstrate that Tuberatolide B inhibits tumor growth in breast, lung, colon, prostate, and cervical cancer cells. Tuberatolide B suppressed cancer cell viability (breast cancer, lung cancer, colon cancer, prostate cancer, cervical cancer). In addition, Tuberatolide B did not affect normal monkey kidney epithelial cell viabilities. Tuberatolide B enhanced DNA damage and ROS generation and inhibited STAT3 activation. In addition, TTB-induced ROS generation caused STAT3 inhibition, DNA damage, and apoptotic cell death. Therefore, Tuberatolide B inhibits cancer development by inducing ROS-mediated suppression of STAT3 signaling, suggesting that TTB is useful for the treatment of cancer.enoid isolated from the Korean marine algae Sargassum macrocarpum. However, the anticancer effects of Tuberatolide B remain unknown. In this study, we demonstrate that Tuberatolide B inhibits tumor growth in breast, lung, colon, prostate, and cervical cancer cells. Tuberatolide B suppressed cancer cell viability (breast cancer, lung cancer, colon cancer, prostate cancer, cervical cancer). In addition, Tuberatolide B did not affect normal monkey kidney epithelial cell viabilities. Tuberatolide B enhanced DNA damage and ROS generation and inhibited STAT3 activation. In addition, TTB-induced ROS generation caused STAT3 inhibition, DNA damage, and apoptotic cell death. Therefore, Tuberatolide B inhibits cancer development by inducing ROS-mediated suppression of STAT3 signaling, suggesting that TTB is useful for the treatment of cancer. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | KSBMB(생화학생물분자학) | - |
dc.relation.isPartOf | KSBMB International Concerence 2017 | - |
dc.title | TuberatolideB의 STAT3 기전을 통하여 ROS의 activation에 의한 세포사멸 효과 | - |
dc.title.alternative | Induction of apoptotic cell death through activating ROS-Mediated inhibition of STAT3 Signalinf pathway by TuberatolideB | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 125 | - |
dc.citation.startPage | 125 | - |
dc.citation.title | KSBMB International Concerence 2017 | - |
dc.contributor.alternativeName | 최윤경 | - |
dc.contributor.alternativeName | 김준성 | - |
dc.contributor.alternativeName | 예보람 | - |
dc.contributor.alternativeName | 김민선 | - |
dc.contributor.alternativeName | 김은아 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | KSBMB International Concerence 2017, pp.125 | - |
dc.description.journalClass | 1 | - |