Metabolic Changes in Marine Medaka Fish (Oryzias javanicus) in Response to Acute 4-nonlyphenol Toxicity
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Title
- Metabolic Changes in Marine Medaka Fish (Oryzias javanicus) in Response to Acute 4-nonlyphenol Toxicity
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Author(s)
- Yum, Seungshic; Jo, Ye Jin; Woo, Seonock
- KIOST Author(s)
- Yum, Seung Shic(염승식); Jo, Ye Jin(조예진); Woo, Seon Ock(우선옥)
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Alternative Author(s)
- 염승식; 조예진; 우선옥
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Publication Year
- 2015-12-20
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Abstract
- The differentially expressed genes in the liver tissue of the marine medaka fish, Oryzias javanicus, were profiled using an oligo-microarray (EnviHaz Fish Array ver. 01) after the fish were exposed to 20 mu g/L 4-nonylphenol (4-NP) for 12, 24, 48, or 72 h to determine the metabolic and physiological changes with exposure time. The transcriptomic changes were highly dynamic in the 4-NP-exposed fish in that among the 216 differentially expressed genes identified in all four exposed fish groups, 106 genes (49.1%) appeared after a specific exposure time. The differentially expressed genes were used to predict the changes that occurred in the metabolic pathways and processes in response to 4-NP exposure. Many physiological and metabolic changes were detected in the early phase of exposure. Significant vitellogenin expression and an estrogenic stimulus response were observed in the fish exposed to 4-NP for 48 h. These results extend our understanding of the biological responses to environmental chemicals at the molecular level and will allow the toxic effects of environmental chemicals, especially endocrine-disrupting chemicals, to be evaluated.
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ISSN
- 1976-0280
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2348
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DOI
- 10.1007/s13206-015-9408-8
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Bibliographic Citation
- BIOCHIP JOURNAL, v.9, no.4, pp.322 - 331, 2015
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Publisher
- KOREAN BIOCHIP SOCIETY-KBCS
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Subject
- GENE-EXPRESSION PROFILE; BISPHENOL-A EXPOSURE; ENVIRONMENTAL SALINITY; ENDOCRINE-DISRUPTION; AQUATIC ENVIRONMENT; RAINBOW-TROUT; RECEPTOR; 4-NONYLPHENOL; HORMONE; NONYLPHENOL
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Keywords
- Endocrine-disrupting chemicals; Differential gene expression profile; Oligo-microarray
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Type
- Article
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Language
- English
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Document Type
- Article
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