Metabolic Changes in Marine Medaka Fish (Oryzias javanicus) in Response to Acute 4-nonlyphenol Toxicity SCIE SCOPUS KCI
DC Field | Value | Language |
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dc.contributor.author | Yum, Seungshic | - |
dc.contributor.author | Jo, Ye Jin | - |
dc.contributor.author | Woo, Seonock | - |
dc.date.accessioned | 2020-04-20T02:55:52Z | - |
dc.date.available | 2020-04-20T02:55:52Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2015-12-20 | - |
dc.identifier.issn | 1976-0280 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/2348 | - |
dc.description.abstract | The differentially expressed genes in the liver tissue of the marine medaka fish, Oryzias javanicus, were profiled using an oligo-microarray (EnviHaz Fish Array ver. 01) after the fish were exposed to 20 mu g/L 4-nonylphenol (4-NP) for 12, 24, 48, or 72 h to determine the metabolic and physiological changes with exposure time. The transcriptomic changes were highly dynamic in the 4-NP-exposed fish in that among the 216 differentially expressed genes identified in all four exposed fish groups, 106 genes (49.1%) appeared after a specific exposure time. The differentially expressed genes were used to predict the changes that occurred in the metabolic pathways and processes in response to 4-NP exposure. Many physiological and metabolic changes were detected in the early phase of exposure. Significant vitellogenin expression and an estrogenic stimulus response were observed in the fish exposed to 4-NP for 48 h. These results extend our understanding of the biological responses to environmental chemicals at the molecular level and will allow the toxic effects of environmental chemicals, especially endocrine-disrupting chemicals, to be evaluated. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | KOREAN BIOCHIP SOCIETY-KBCS | - |
dc.subject | GENE-EXPRESSION PROFILE | - |
dc.subject | BISPHENOL-A EXPOSURE | - |
dc.subject | ENVIRONMENTAL SALINITY | - |
dc.subject | ENDOCRINE-DISRUPTION | - |
dc.subject | AQUATIC ENVIRONMENT | - |
dc.subject | RAINBOW-TROUT | - |
dc.subject | RECEPTOR | - |
dc.subject | 4-NONYLPHENOL | - |
dc.subject | HORMONE | - |
dc.subject | NONYLPHENOL | - |
dc.title | Metabolic Changes in Marine Medaka Fish (Oryzias javanicus) in Response to Acute 4-nonlyphenol Toxicity | - |
dc.type | Article | - |
dc.citation.endPage | 331 | - |
dc.citation.startPage | 322 | - |
dc.citation.title | BIOCHIP JOURNAL | - |
dc.citation.volume | 9 | - |
dc.citation.number | 4 | - |
dc.contributor.alternativeName | 염승식 | - |
dc.contributor.alternativeName | 조예진 | - |
dc.contributor.alternativeName | 우선옥 | - |
dc.identifier.bibliographicCitation | BIOCHIP JOURNAL, v.9, no.4, pp.322 - 331 | - |
dc.identifier.doi | 10.1007/s13206-015-9408-8 | - |
dc.identifier.scopusid | 2-s2.0-84952320270 | - |
dc.identifier.wosid | 000367026800008 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002057133 | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GENE-EXPRESSION PROFILE | - |
dc.subject.keywordPlus | BISPHENOL-A EXPOSURE | - |
dc.subject.keywordPlus | ENVIRONMENTAL SALINITY | - |
dc.subject.keywordPlus | ENDOCRINE-DISRUPTION | - |
dc.subject.keywordPlus | AQUATIC ENVIRONMENT | - |
dc.subject.keywordPlus | RAINBOW-TROUT | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | 4-NONYLPHENOL | - |
dc.subject.keywordPlus | HORMONE | - |
dc.subject.keywordPlus | NONYLPHENOL | - |
dc.subject.keywordAuthor | Endocrine-disrupting chemicals | - |
dc.subject.keywordAuthor | Differential gene expression profile | - |
dc.subject.keywordAuthor | Oligo-microarray | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |