해양 곰팡이 Mycosphaerella sp. 135PIL286 유래의 신규 아줄린 계열 화합물

Title
해양 곰팡이 Mycosphaerella sp. 135PIL286 유래의 신규 아줄린 계열 화합물
Alternative Title
A Novel Azulene Compound from a Marine Fungus Mycosphaerella sp. 135PIL286
Author(s)
이화선; 최병규; 이희승; 이종석; 이연주; 이지훈; 신희재
KIOST Author(s)
Lee, Hwa Sun(이화선)Choi, Byeoung Kyu(최병규)Lee, Hyi Seung(이희승)Lee, Jong Seok(이종석)Lee, Yeon Ju(이연주)Lee, Jihoon(이지훈)
Publication Year
2018-04-19
Abstract
Marine microorganisms are recognized as an important source for drug discovery because microbes produce compounds having different skeleton and diverse bioactivities than terrestrial counterparts [1, 2]. Various compounds of azulene class have been reported from the marine brown alga. And these compounds showed anti-microbial, anti-cancer and anti-viral activities [3, 4, 5]. Interestingly, in this study, we isolated and purified a novel azulene compound from the extract of culture broth of the marine fungus Mycosphaerella sp. 135PIL286 by chromatographic methods. The planar structure of the new compound was elucidated by analysis of 1D, 2D NMR and LC-MS data. And its relative stereochemistry was determined by detailed analyses of coupling constants and NOESY data.ave been reported from the marine brown alga. And these compounds showed anti-microbial, anti-cancer and anti-viral activities [3, 4, 5]. Interestingly, in this study, we isolated and purified a novel azulene compound from the extract of culture broth of the marine fungus Mycosphaerella sp. 135PIL286 by chromatographic methods. The planar structure of the new compound was elucidated by analysis of 1D, 2D NMR and LC-MS data. And its relative stereochemistry was determined by detailed analyses of coupling constants and NOESY data.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/23427
Bibliographic Citation
2018 한국생물공학회 춘계학술발표대회, pp.1, 2018
Publisher
한국생물공학회
Type
Conference
Language
English
Publisher
한국생물공학회
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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