Anti-Inflammatory Activity of Tanzawaic Acid Derivatives from a Marine-Derived Fungus Penicillium steckii 108YD142
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Title
- Anti-Inflammatory Activity of Tanzawaic Acid Derivatives from a Marine-Derived Fungus Penicillium steckii 108YD142
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Author(s)
- Shin, Hee Jae; Pil, Gam Bang; Heo, Soo-Jin; Lee, Hyi-Seung; Lee, Jong Seok; Lee, Yeon-Ju; Lee, Jihoon; Won, Ho Shik
- KIOST Author(s)
- Shin, Hee Jae(신희재); Heo, Soo Jin(허수진); Lee, Hyi Seung(이희승); Lee, Jong Seok(이종석); Lee, Yeon Ju(이연주); Lee, Ji Hoon(이지훈)
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Alternative Author(s)
- 신희재; 필감방; 허수진; 이희승; 이종석; 이연주; 이지훈
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Publication Year
- 2016-01
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Abstract
- Chemical investigation of a marine-derived fungus, Penicillium steckii 108YD142, resulted in the discovery of a new tanzawaic acid derivative, tanzawaic acid Q (1), together with four known analogues, tanzawaic acids A (2), C (3), D (4), and K (5). The structures of tanzawaic acid derivatives 1-5 were determined by the detailed analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis. These compounds significantly inhibited nitric oxide (NO) production and the new tanzawaic acid Q (1) inhibited the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins and mRNA expressions in RAW 264.7 macrophages. Additionally, compound 1 reduced the mRNA levels of inflammatory cytokines. Taken together, the results of this study demonstrated that the new tanzawaic acid derivative inhibits LPS-induced inflammation. This is the first report on the anti-inflammatory activity of tanzawaic acid Q (1).
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ISSN
- 1660-3397
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2295
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DOI
- 10.3390/md14010014
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Bibliographic Citation
- MARINE DRUGS, v.14, no.1, 2016
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Publisher
- MDPI AG
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Subject
- CITRINUM; POLYKETIDES
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Keywords
- marine fungus; Penicillium steckii; tanzawaic acids; anti-inflammatory
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Type
- Article
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Language
- English
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Document Type
- Article
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