Anti-Inflammatory Activity of Tanzawaic Acid Derivatives from a Marine-Derived Fungus Penicillium steckii 108YD142 SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Shin, Hee Jae | - |
dc.contributor.author | Pil, Gam Bang | - |
dc.contributor.author | Heo, Soo-Jin | - |
dc.contributor.author | Lee, Hyi-Seung | - |
dc.contributor.author | Lee, Jong Seok | - |
dc.contributor.author | Lee, Yeon-Ju | - |
dc.contributor.author | Lee, Jihoon | - |
dc.contributor.author | Won, Ho Shik | - |
dc.date.accessioned | 2020-04-20T02:55:24Z | - |
dc.date.available | 2020-04-20T02:55:24Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/2295 | - |
dc.description.abstract | Chemical investigation of a marine-derived fungus, Penicillium steckii 108YD142, resulted in the discovery of a new tanzawaic acid derivative, tanzawaic acid Q (1), together with four known analogues, tanzawaic acids A (2), C (3), D (4), and K (5). The structures of tanzawaic acid derivatives 1-5 were determined by the detailed analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis. These compounds significantly inhibited nitric oxide (NO) production and the new tanzawaic acid Q (1) inhibited the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins and mRNA expressions in RAW 264.7 macrophages. Additionally, compound 1 reduced the mRNA levels of inflammatory cytokines. Taken together, the results of this study demonstrated that the new tanzawaic acid derivative inhibits LPS-induced inflammation. This is the first report on the anti-inflammatory activity of tanzawaic acid Q (1). | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.subject | CITRINUM | - |
dc.subject | POLYKETIDES | - |
dc.title | Anti-Inflammatory Activity of Tanzawaic Acid Derivatives from a Marine-Derived Fungus Penicillium steckii 108YD142 | - |
dc.type | Article | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.contributor.alternativeName | 신희재 | - |
dc.contributor.alternativeName | 필감방 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.contributor.alternativeName | 이종석 | - |
dc.contributor.alternativeName | 이연주 | - |
dc.contributor.alternativeName | 이지훈 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.14, no.1 | - |
dc.identifier.doi | 10.3390/md14010014 | - |
dc.identifier.scopusid | 2-s2.0-84955444112 | - |
dc.identifier.wosid | 000374586800014 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CITRINUM | - |
dc.subject.keywordPlus | POLYKETIDES | - |
dc.subject.keywordAuthor | marine fungus | - |
dc.subject.keywordAuthor | Penicillium steckii | - |
dc.subject.keywordAuthor | tanzawaic acids | - |
dc.subject.keywordAuthor | anti-inflammatory | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |