The Isolation and Structure Elucidation of Isomalabaricane Triterpenoids Isolated from Marine Sponge Rhabdastrella globostellata collected in Bohol, Philippines

Title
The Isolation and Structure Elucidation of Isomalabaricane Triterpenoids Isolated from Marine Sponge Rhabdastrella globostellata collected in Bohol, Philippines
Author(s)
김수현; 이연주
KIOST Author(s)
Lee, Yeon Ju(이연주)
Publication Year
2018-11-08
Abstract
The growth inhibitory activity screening of Tropical sponge extracts revealed that the crude extract of Rhabdastrella globostellata colleted in Bohol, The Philippines, efficiently inhibits the growth of human leukemia cell line (K562, IC50 values 0.8μg/mL). Natural products contained in this extract were investigated, in order to discover the cytotoxic metabolite, which resulted in the isolation of isomalabaricane triterpenoids - stellettin A, B, isogeoditin A, 13(E)-isogeoditin A, and geoditin A. The growth inhibitory activities of the isolated compounds against several cancer cell lines are now under investigation.values 0.8μg/mL). Natural products contained in this extract were investigated, in order to discover the cytotoxic metabolite, which resulted in the isolation of isomalabaricane triterpenoids - stellettin A, B, isogeoditin A, 13(E)-isogeoditin A, and geoditin A. The growth inhibitory activities of the isolated compounds against several cancer cell lines are now under investigation.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/22893
Bibliographic Citation
Journal of Marine Bioscience and Biotechnology, pp.205, 2018
Publisher
한국해양바이오학회
Type
Conference
Language
English
Publisher
한국해양바이오학회
Related Researcher
Research Interests

Marine Natural Product,Natural Product Biosynthesis,Medicinal Chemistry,해양 천연물,천연물 생합성,의약화학

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