Saringosterol acetate는 zebrafish 모델에서 간세포 암종 억제

Title
Saringosterol acetate는 zebrafish 모델에서 간세포 암종 억제
Alternative Title
Saringosterol acetate suppresses hepatocellular carcinoma in zebrafish models
Author(s)
김은아; 김준성; 전유진; 허수진
KIOST Author(s)
Kim, Eun A(김은아)Kim, Junseong(김준성)Heo, Soo Jin(허수진)
Publication Year
2018-11-22
Abstract
Hizikia fusiforme, an edible brown alga widely consumed in Korea, Japan, and China has been found to possess a number of potential biological functionalities. The present study assessed the potent anti-cancer effects of saringostrol acetate (SSA) isolated from the H. fusiforme towards the inhibitory effects on hepatocellular carcinoma in Hep3B cell. SSA markedly inhibited cancer cell growth, attenuating the population of cells in sub-G1 through PI3K/Akt/mTOR pathway. Furtherstudies elaborate the therapeutic effects of SSA against diethylnitrosamin (DEN)-stimulated cancer in zebrafish model. DEN exposure caused a marked increase in reactive oxygen species (ROS) production, cell death, and expression of transforming growth factor beta (TGFβ) and metalloprotease 2 (MMP2) in zebrafish. However, treatment with SSA significantly downregulated DEN-induced ROS, cell death, and TGFβ and MMP2 expressions. These results support the potential anticancer effects of SSA and highlight its potential applications related to nutraceuticals or functional food to reduce the carcinogenic effect. (SSA) isolated from the H. fusiforme towards the inhibitory effects on hepatocellular carcinoma in Hep3B cell. SSA markedly inhibited cancer cell growth, attenuating the population of cells in sub-G1 through PI3K/Akt/mTOR pathway. Furtherstudies elaborate the therapeutic effects of SSA against diethylnitrosamin (DEN)-stimulated cancer in zebrafish model. DEN exposure caused a marked increase in reactive oxygen species (ROS) production, cell death, and expression of transforming growth factor beta (TGFβ) and metalloprotease 2 (MMP2) in zebrafish. However, treatment with SSA significantly downregulated DEN-induced ROS, cell death, and TGFβ and MMP2 expressions. These results support the potential anticancer effects of SSA and highlight its potential applications related to nutraceuticals or functional food to reduce the carcinogenic effect.
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/22862
Bibliographic Citation
KoSFoST, pp.129, 2018
Publisher
한국식품과학회
Type
Conference
Language
English
Publisher
한국식품과학회
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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