Saringosterol acetae Inhibits Liver Cancer Progression via PI3K/Akt/mTOR Signaling in A Zerafish Xenograft model

Title
Saringosterol acetae Inhibits Liver Cancer Progression via PI3K/Akt/mTOR Signaling in A Zerafish Xenograft model
Author(s)
김은아; 김준성; 강나래; You-Jin Jeon; 허수진
KIOST Author(s)
Kim, Eun A(김은아)Kim, Junseong(김준성)Kang, Nalae(강나래)Heo, Soo Jin(허수진)
Publication Year
2019-04-30
Abstract
Background : Hizikia fusiforme has been found to possess a number of potential biological functionalities but just a few reports have revealed for the relationship between activities and compounds. The zebrafish model system is one of the most widely used animal models. That is attaining popularity as becomes an attractive model for molecular genetics, developmental biology, drug discovery and screening of human disease. In this study, we established that inhibition of livercancer progression effects was occurred in human cancer cell xenograft zebrafish model. Methods : The zebrafish were injected with saringosterol acetate (SSA) isolated from Hizikia fusiforme every three days. After a week, the abdominal cavity of zebrafish was inoculated with Hep3B cells during ten times a month.Results : Angiogenic factors (VEGF, TGFβ, MMP2, MMP9, IL6, and TNF-α), and α-fetoprotien (AFP) production were significantly increased in HepB cells-injected group compared with normal group. However, SSA considerably inhibited angiogenic factors and AFP production. Further mechanistic studies showed that SSA-injected group suppressed TGFβ pathways and phosphorylation of PI3k/Akt/mTOR pathways in the liver tissues treated with SSA
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/22742
Bibliographic Citation
International Seaweed Symposium, pp.177, 2019
Publisher
The Korean Society of Phycology
Type
Conference
Language
English
Publisher
The Korean Society of Phycology
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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