Callyazepin and (3R)-Methylazacyclodecane, Nitrogenous Macrocycles from a Callyspongia sp Sponge SCIE SCOPUS

Cited 10 time in WEB OF SCIENCE Cited 11 time in Scopus
Title
Callyazepin and (3R)-Methylazacyclodecane, Nitrogenous Macrocycles from a Callyspongia sp Sponge
Author(s)
Kim, Chang-Kwon; Woo, Jung-Kyun; Lee, Yeon-Ju; Lee, Hyi-Seung; Sim, Chung J.; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)
Publication Year
2016-04
Abstract
Callyazepin (1) and (3R)-methylazacyclodecane (2), nitrogenous macrocycles, were isolated from a tropical Callyspongia sp. sponge. The combined spectroscopic analyses revealed that the structure of 1 is a bicyclic azepane ammonium salt of a novel structural class derived from mixed biogenetic origins. The configuration of the whole molecule and the conformation of the formamide group were assigned by proton-proton coupling constants, a NOESY analysis, and the application of the phenylglycine methyl ester method. The structure of 2 was identified using combined spectroscopic analyses and ECD measurements. These compounds exhibited moderate cytotoxic activities against the K562 and A549 cell lines.
ISSN
0163-3864
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/2207
DOI
10.1021/acs.jnatprod.5b01078
Bibliographic Citation
JOURNAL OF NATURAL PRODUCTS, v.79, no.4, pp.1179 - 1183, 2016
Publisher
AMER CHEMICAL SOC
Subject
MARINE NATURAL-PRODUCTS; ABSOLUTE-CONFIGURATION; HALICLONA-TULEARENSIS; CIRCULAR-DICHROISM; DNP DERIVATIVES; RENIERA-SARAI; AMINO-ACIDS; HALICLORENSIN; METABOLITES; HALITULIN
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
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