Differential Toxicokinetics Determines the Sensitivity of Two Marine Embryonic Fish Exposed to Iranian Heavy Crude Oil
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Title
- Differential Toxicokinetics Determines the Sensitivity of Two Marine Embryonic Fish Exposed to Iranian Heavy Crude Oil
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Author(s)
- Jung, Jee-Hyun; Kim, Moonkoo; Yim, Un Hyuk; Ha, Sung Yong; Shim, Won Joon; Chae, Young Sun; Kim, Hana; Incardona, John P.; Linbo, Tiffany L.; Kwon, Jung-Hwan
- KIOST Author(s)
- Jung, Jee Hyun(정지현); Kim, Moon Koo(김문구); Yim, Un Hyuk(임운혁); Ha, Sung Yong(하성용); Shim, Won Joon(심원준)
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Alternative Author(s)
- 정지현; 김문구; 임운혁; 하성용; 심원준
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Publication Year
- 2015-11-17
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Abstract
- Interspecific difference in the developmental toxicity of crude oil to embryonic fish allows the prediction of injury extent to a number of resident fish species in oil spill sites. This study clarifies the comparative developmental effects of Iranian heavy crude oil (IHCO) on the differences of biouptake and toxic sensitivity between embryonic spotted sea bass (Lateolabrax maculates) and olive flounder (Paralichthys olivaceus). From 24 h after exposure to IHCO, several morphological defects were observed in both species of embryonic fish, including pericardial edema, dorsal curvature of the trunk, developmental delay, and reduced finfolds. The severity of defects was greater in flounder compared to that in sea bass. While flounder embryos accumulated higher embryo PAH concentrations than sea bass, the former showed significantly lower levels of CYP1A expression. Although bioconcentration ratios were similar between the two species for some PAHs, phenanthrenes and dibenzothiophenes showed selectively higher bioconcentration ratios in flounder, suggesting that this species has a reduced metabolic capacity for these compounds. While consistent with a conserved cardiotoxic mechanism for petrogenic PAHs across diverse marine and freshwater species, these findings indicate that species-specific differences in toxicokinetics can be an important factor underlying species' sensitivity to crude oil.
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ISSN
- 0013-936X
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/2089
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DOI
- 10.1021/acs.est.5b03729
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Bibliographic Citation
- ENVIRONMENTAL SCIENCE & TECHNOLOGY, v.49, no.22, pp.13639 - 13648, 2015
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Publisher
- AMER CHEMICAL SOC
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Subject
- POLYCYCLIC AROMATIC-HYDROCARBONS; SALMON ONCORHYNCHUS-GORBUSCHA; HERRING CLUPEA-PALLASI; EARLY-LIFE STAGES; EXXON-VALDEZ; DEVELOPMENTAL TOXICITY; ZEBRAFISH; KOREA; SPILL; MORTALITY
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Type
- Article
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Language
- English
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Document Type
- Article
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