박테리아에서 유래한 아키아와 같은 특징을 가진 새로운 샤페로닌의 구조분석
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안영준 | - |
dc.contributor.author | 차선신 | - |
dc.date.accessioned | 2020-05-18T05:07:21Z | - |
dc.date.available | 2020-05-18T05:07:21Z | - |
dc.date.created | 2020-05-18 | - |
dc.date.issued | 2018-06-27 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/20446 | - |
dc.description.abstract | The chaperonins (CPNs) are megadalton sized hollow complexes with two cavities that open and close to encapsulate non-native proteins. CPNs are assigned to two sequence-related groups that have distinct allosteric mechanisms. In Group I CPNs a detachable co-chaperone, GroES, closes the chambers whereas in Group II a built-in lid closes the chambers. Group I CPNs have a bacterial ancestry, whereas Group II CPNs are archaeal in origin. Here we describe open and closed crystal structures representing a new phylogenetic branch of CPNs. These Group III CPNs are divergent in sequence and structure from extant CPNs, but are closed by a built-in lid like Group II CPNs. A nucleotide-sensing loop, present in both Group I and Group II CPNs, is notably absent. We identified inter-ring pivot joints that articulate during ring closure. These Group III CPNs likely represent a relic from the ancestral CPN that formed distinct bacterial and archaeal branches.s a detachable co-chaperone, GroES, closes the chambers whereas in Group II a built-in lid closes the chambers. Group I CPNs have a bacterial ancestry, whereas Group II CPNs are archaeal in origin. Here we describe open and closed crystal structures representing a new phylogenetic branch of CPNs. These Group III CPNs are divergent in sequence and structure from extant CPNs, but are closed by a built-in lid like Group II CPNs. A nucleotide-sensing loop, present in both Group I and Group II CPNs, is notably absent. We identified inter-ring pivot joints that articulate during ring closure. These Group III CPNs likely represent a relic from the ancestral CPN that formed distinct bacterial and archaeal branches. | - |
dc.description.uri | 2 | - |
dc.language | Korean | - |
dc.publisher | 한국구조생물학회 | - |
dc.relation.isPartOf | 2018 International Conference of the Korean Society for Structural Biology | - |
dc.title | 박테리아에서 유래한 아키아와 같은 특징을 가진 새로운 샤페로닌의 구조분석 | - |
dc.title.alternative | Structural Analysis of Novel Archaeal-like Chaperonin from a Thermphilic bacterium | - |
dc.type | Conference | - |
dc.citation.conferencePlace | KO | - |
dc.citation.endPage | 15 | - |
dc.citation.startPage | 15 | - |
dc.citation.title | 2018 International Conference of the Korean Society for Structural Biology | - |
dc.contributor.alternativeName | 안영준 | - |
dc.identifier.bibliographicCitation | 2018 International Conference of the Korean Society for Structural Biology, pp.15 | - |
dc.description.journalClass | 2 | - |