GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase
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Title
- GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase
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Author(s)
- Na, J.-H.; An, Y.J.; Cha, S.-S.
- KIOST Author(s)
- An, Young Jun(안영준)
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Alternative Author(s)
- 안영준
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Publication Year
- 2017-05
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Abstract
- Nucleotides were effective in inhibiting the class C β-lactamase CMY-10. IMP was the most potent competitive inhibitor, with a Ki value of 16.2 μM. The crystal structure of CMY-10 complexed with GMP or IMP revealed that nucleotides fit into the R2 subsite of the active site with a unique vertical binding mode where the phosphate group at one terminus is deeply bound in the subsite and the base at the other terminus faces the solvent. Copyright © 2017 American Society for Microbiology. All Rights Reserved.
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ISSN
- 0066-4804
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/1242
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DOI
- 10.1128/AAC.00098-17
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Bibliographic Citation
- Antimicrobial Agents and Chemotherapy, v.61, no.5, 2017
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Publisher
- American Society for Microbiology
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Keywords
- Competitive inhibitor; GMP; IMP; β-lactamases
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Type
- Article
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Language
- English
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Document Type
- Article
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