GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase SCIE SCOPUS
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- Title
- GMP and IMP Are Competitive Inhibitors of CMY-10, an Extended-Spectrum Class C beta-Lactamase
- KIOST Author(s)
- An, Young Jun(안영준)
- Alternative Author(s)
- 안영준
- Publication Year
- 2017-05
- Abstract
- Nucleotides were effective in inhibiting the class C β-lactamase CMY-10. IMP was the most potent competitive inhibitor, with a Ki value of 16.2 μM. The crystal structure of CMY-10 complexed with GMP or IMP revealed that nucleotides fit into the R2 subsite of the active site with a unique vertical binding mode where the phosphate group at one terminus is deeply bound in the subsite and the base at the other terminus faces the solvent. Copyright © 2017 American Society for Microbiology. All Rights Reserved.
- ISSN
- 0066-4804
- Bibliographic Citation
- Antimicrobial Agents and Chemotherapy, v.61, no.5, 2017
- Publisher
- American Society for Microbiology
- Keywords
- Competitive inhibitor; GMP; IMP; β-lactamases
- Type
- Article
- Language
- English
- Document Type
- Article
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- There are no files associated with this item.
