Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis SCIE SCOPUS

Cited 9 time in WEB OF SCIENCE Cited 8 time in Scopus
Title
Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis
Author(s)
Tareq, Fakir Shahidullah; Shin, Hee Jae
Publication Year
2017-11
Abstract
LC-MS and NMR spectroscopy guided metabolic profiling and dereplication of a crude extract obtained from the fermentation of a marine-derived bacterium, Bacillus subtilis, followed by chromatographic isolation yielded two new cyclic-lipotetrapeptides, bacilotetrins A (1) and B (2). Based on extensive 1D and 2D NMR and high-resolution ESIMS data analysis, the structures of 1 and 2 were elucidated, revealing the unique structures of these lipopeptides consisting of three leucines and a glutamic acid residue cyclized with a lipophilic 3-hydroxy fatty acid. The absolute stereochemistries at selected stereocenters in 1 and 2 were assigned by chemical derivatization and comparison to literature data. Compounds 1 and 2 exhibited anti-MRSA activity with MIC values of 8 to mu g/mL. However, these compounds showed no cytotoxicity when tested against prostate and liver cancer cell lines using the standard SRB assay.
ISSN
0163-3864
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1130
DOI
10.1021/acs.jnatprod.7b00356
Bibliographic Citation
JOURNAL OF NATURAL PRODUCTS, v.80, no.11, pp.2889 - 2892, 2017
Publisher
AMER CHEMICAL SOC
Subject
ANTIMICROBIAL LINEAR LIPOPEPTIDES; A-C; METABOLITES; GROWTH
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
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