Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis
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Title
- Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis
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Author(s)
- Tareq, Fakir Shahidullah; Shin, Hee Jae
- KIOST Author(s)
- Shin, Hee Jae(신희재)
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Alternative Author(s)
- 신희재
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Publication Year
- 2017-11
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Abstract
- LC-MS and NMR spectroscopy guided metabolic profiling and dereplication of a crude extract obtained from the fermentation of a marine-derived bacterium, Bacillus subtilis, followed by chromatographic isolation yielded two new cyclic-lipotetrapeptides, bacilotetrins A (1) and B (2). Based on extensive 1D and 2D NMR and high-resolution ESIMS data analysis, the structures of 1 and 2 were elucidated, revealing the unique structures of these lipopeptides consisting of three leucines and a glutamic acid residue cyclized with a lipophilic 3-hydroxy fatty acid. The absolute stereochemistries at selected stereocenters in 1 and 2 were assigned by chemical derivatization and comparison to literature data. Compounds 1 and 2 exhibited anti-MRSA activity with MIC values of 8 to mu g/mL. However, these compounds showed no cytotoxicity when tested against prostate and liver cancer cell lines using the standard SRB assay.
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ISSN
- 0163-3864
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/1130
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DOI
- 10.1021/acs.jnatprod.7b00356
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Bibliographic Citation
- JOURNAL OF NATURAL PRODUCTS, v.80, no.11, pp.2889 - 2892, 2017
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Publisher
- AMER CHEMICAL SOC
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Subject
- ANTIMICROBIAL LINEAR LIPOPEPTIDES; A-C; METABOLITES; GROWTH
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Type
- Article
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Language
- English
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Document Type
- Article
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