Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Tareq, Fakir Shahidullah | - |
dc.contributor.author | Shin, Hee Jae | - |
dc.date.accessioned | 2020-04-16T09:55:13Z | - |
dc.date.available | 2020-04-16T09:55:13Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/1130 | - |
dc.description.abstract | LC-MS and NMR spectroscopy guided metabolic profiling and dereplication of a crude extract obtained from the fermentation of a marine-derived bacterium, Bacillus subtilis, followed by chromatographic isolation yielded two new cyclic-lipotetrapeptides, bacilotetrins A (1) and B (2). Based on extensive 1D and 2D NMR and high-resolution ESIMS data analysis, the structures of 1 and 2 were elucidated, revealing the unique structures of these lipopeptides consisting of three leucines and a glutamic acid residue cyclized with a lipophilic 3-hydroxy fatty acid. The absolute stereochemistries at selected stereocenters in 1 and 2 were assigned by chemical derivatization and comparison to literature data. Compounds 1 and 2 exhibited anti-MRSA activity with MIC values of 8 to mu g/mL. However, these compounds showed no cytotoxicity when tested against prostate and liver cancer cell lines using the standard SRB assay. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | ANTIMICROBIAL LINEAR LIPOPEPTIDES | - |
dc.subject | A-C | - |
dc.subject | METABOLITES | - |
dc.subject | GROWTH | - |
dc.title | Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-Derived Bacillus subtilis | - |
dc.type | Article | - |
dc.citation.endPage | 2892 | - |
dc.citation.startPage | 2889 | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 80 | - |
dc.citation.number | 11 | - |
dc.contributor.alternativeName | 신희재 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.80, no.11, pp.2889 - 2892 | - |
dc.identifier.doi | 10.1021/acs.jnatprod.7b00356 | - |
dc.identifier.scopusid | 2-s2.0-85034952107 | - |
dc.identifier.wosid | 000416500400004 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANTIMICROBIAL LINEAR LIPOPEPTIDES | - |
dc.subject.keywordPlus | A-C | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | GROWTH | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |