Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp. SCIE SCOPUS

DC Field Value Language Shin, Hee Jae - Choi, Byeoung-Kyu - Phan Thi Hoai Trinh - Lee, Hwa-Sun - Kang, Jong Soon - Tran Thi Thanh Van - Lee, Hyi-Seung - Lee, Jong Seok - Lee, Yeon-Ju - Lee, Jihoon - 2020-04-16T09:40:07Z - 2020-04-16T09:40:07Z - 2020-01-28 - 2018-01 -
dc.identifier.issn 1660-3397 -
dc.identifier.uri -
dc.description.abstract A new -pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), and mactanamide (5), were isolated from the marine fungus Aspergillus flocculosus derived from a sponge Stylissa sp. collected in Vietnam. The structures of Compounds 1-5 were elucidated by analysis of 1D and 2D NMR spectra and MS data. All the isolated compounds were evaluated for anti-proliferation activity and their suppression effects on receptor activator of nuclear factor B ligand (RANKL)-induced osteoclast differentiation using tartate-resisant acid phosphatase (TRAP). Compounds 1-5 had no anti-proliferative effect on human cancer cell lines up to 30 g/mL. Among these compounds, aspertetranone D (2) and wasabidienone E (4) exhibited weak osteoclast differentiation inhibitory activity at 10 g/mL. However, mactanamide (5) showed a potent suppression effect of osteoclast differentiation without any evidence of cytotoxicity. -
dc.description.uri 1 -
dc.language English -
dc.publisher MDPI AG -
dc.subject MICROBES -
dc.subject DERIVATIVES -
dc.subject RESORPTION -
dc.subject AGENTS -
dc.title Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp. -
dc.type Article -
dc.citation.title MARINE DRUGS -
dc.citation.volume 16 -
dc.citation.number 1 -
dc.contributor.alternativeName 신희재 -
dc.contributor.alternativeName 최병규 -
dc.contributor.alternativeName 이화선 -
dc.contributor.alternativeName 이희승 -
dc.contributor.alternativeName 이종석 -
dc.contributor.alternativeName 이연주 -
dc.contributor.alternativeName 이지훈 -
dc.identifier.bibliographicCitation MARINE DRUGS, v.16, no.1 -
dc.identifier.doi 10.3390/md16010014 -
dc.identifier.scopusid 2-s2.0-85040445718 -
dc.identifier.wosid 000424125600014 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.subject.keywordPlus NATURAL-PRODUCTS -
dc.subject.keywordPlus DIFFERENTIATION -
dc.subject.keywordPlus MICROBES -
dc.subject.keywordPlus DERIVATIVES -
dc.subject.keywordPlus RESORPTION -
dc.subject.keywordPlus AGENTS -
dc.subject.keywordAuthor mactanamide -
dc.subject.keywordAuthor osteoclastogenesis -
dc.subject.keywordAuthor marine fungus -
dc.subject.keywordAuthor Aspergillus flocculosus -
dc.subject.keywordAuthor TRAP assay -
dc.relation.journalWebOfScienceCategory Chemistry, Medicinal -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Pharmacology & Pharmacy -
Appears in Collections:
Marine Resources Research Division > Marine Biotechnology Research Center > 1. Journal Articles
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