Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp. SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Shin, Hee Jae | - |
dc.contributor.author | Choi, Byeoung-Kyu | - |
dc.contributor.author | Phan Thi Hoai Trinh | - |
dc.contributor.author | Lee, Hwa-Sun | - |
dc.contributor.author | Kang, Jong Soon | - |
dc.contributor.author | Tran Thi Thanh Van | - |
dc.contributor.author | Lee, Hyi-Seung | - |
dc.contributor.author | Lee, Jong Seok | - |
dc.contributor.author | Lee, Yeon-Ju | - |
dc.contributor.author | Lee, Jihoon | - |
dc.date.accessioned | 2020-04-16T09:40:07Z | - |
dc.date.available | 2020-04-16T09:40:07Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/1038 | - |
dc.description.abstract | A new -pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), and mactanamide (5), were isolated from the marine fungus Aspergillus flocculosus derived from a sponge Stylissa sp. collected in Vietnam. The structures of Compounds 1-5 were elucidated by analysis of 1D and 2D NMR spectra and MS data. All the isolated compounds were evaluated for anti-proliferation activity and their suppression effects on receptor activator of nuclear factor B ligand (RANKL)-induced osteoclast differentiation using tartate-resisant acid phosphatase (TRAP). Compounds 1-5 had no anti-proliferative effect on human cancer cell lines up to 30 g/mL. Among these compounds, aspertetranone D (2) and wasabidienone E (4) exhibited weak osteoclast differentiation inhibitory activity at 10 g/mL. However, mactanamide (5) showed a potent suppression effect of osteoclast differentiation without any evidence of cytotoxicity. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.subject | NATURAL-PRODUCTS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | MICROBES | - |
dc.subject | DERIVATIVES | - |
dc.subject | RESORPTION | - |
dc.subject | AGENTS | - |
dc.title | Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp. | - |
dc.type | Article | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.contributor.alternativeName | 신희재 | - |
dc.contributor.alternativeName | 최병규 | - |
dc.contributor.alternativeName | 이화선 | - |
dc.contributor.alternativeName | 이희승 | - |
dc.contributor.alternativeName | 이종석 | - |
dc.contributor.alternativeName | 이연주 | - |
dc.contributor.alternativeName | 이지훈 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.16, no.1 | - |
dc.identifier.doi | 10.3390/md16010014 | - |
dc.identifier.scopusid | 2-s2.0-85040445718 | - |
dc.identifier.wosid | 000424125600014 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | MICROBES | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | RESORPTION | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordAuthor | mactanamide | - |
dc.subject.keywordAuthor | osteoclastogenesis | - |
dc.subject.keywordAuthor | marine fungus | - |
dc.subject.keywordAuthor | Aspergillus flocculosus | - |
dc.subject.keywordAuthor | TRAP assay | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |