Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp.
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Title
- Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp.
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Author(s)
- Shin, Hee Jae; Choi, Byeoung-Kyu; Phan Thi Hoai Trinh; Lee, Hwa-Sun; Kang, Jong Soon; Tran Thi Thanh Van; Lee, Hyi-Seung; Lee, Jong Seok; Lee, Yeon-Ju; Lee, Jihoon
- KIOST Author(s)
- Shin, Hee Jae(신희재); Lee, Hwa Sun(이화선); Lee, Hyi Seung(이희승); Lee, Jong Seok(이종석); Lee, Yeon Ju(이연주); Lee, Ji Hoon(이지훈)
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Alternative Author(s)
- 신희재; 최병규; 이화선; 이희승; 이종석; 이연주; 이지훈
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Publication Year
- 2018-01
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Abstract
- A new -pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), and mactanamide (5), were isolated from the marine fungus Aspergillus flocculosus derived from a sponge Stylissa sp. collected in Vietnam. The structures of Compounds 1-5 were elucidated by analysis of 1D and 2D NMR spectra and MS data. All the isolated compounds were evaluated for anti-proliferation activity and their suppression effects on receptor activator of nuclear factor B ligand (RANKL)-induced osteoclast differentiation using tartate-resisant acid phosphatase (TRAP). Compounds 1-5 had no anti-proliferative effect on human cancer cell lines up to 30 g/mL. Among these compounds, aspertetranone D (2) and wasabidienone E (4) exhibited weak osteoclast differentiation inhibitory activity at 10 g/mL. However, mactanamide (5) showed a potent suppression effect of osteoclast differentiation without any evidence of cytotoxicity.
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ISSN
- 1660-3397
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/1038
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DOI
- 10.3390/md16010014
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Bibliographic Citation
- MARINE DRUGS, v.16, no.1, 2018
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Publisher
- MDPI AG
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Subject
- NATURAL-PRODUCTS; DIFFERENTIATION; MICROBES; DERIVATIVES; RESORPTION; AGENTS
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Keywords
- mactanamide; osteoclastogenesis; marine fungus; Aspergillus flocculosus; TRAP assay
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Type
- Article
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Language
- English
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Document Type
- Article
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