Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp. SCIE SCOPUS

Cited 15 time in WEB OF SCIENCE Cited 17 time in Scopus
Title
Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp.
Author(s)
Shin, Hee Jae; Choi, Byeoung-Kyu; Phan Thi Hoai Trinh; Lee, Hwa-Sun; Kang, Jong Soon; Tran Thi Thanh Van; Lee, Hyi-Seung; Lee, Jong Seok; Lee, Yeon-Ju; Lee, Jihoon
KIOST Author(s)
Shin, Hee Jae(신희재)Lee, Hwa Sun(이화선)Lee, Hyi Seung(이희승)Lee, Jong Seok(이종석)Lee, Yeon Ju(이연주)Lee, Ji Hoon(이지훈)
Alternative Author(s)
신희재; 최병규; 이화선; 이희승; 이종석; 이연주; 이지훈
Publication Year
2018-01
Abstract
A new -pyrone merosesquiterpenoid possessing an angular tetracyclic carbon skeleton, ochraceopone F (1), and four known secondary metabolites, aspertetranone D (2), cycloechinulin (3), wasabidienone E (4), and mactanamide (5), were isolated from the marine fungus Aspergillus flocculosus derived from a sponge Stylissa sp. collected in Vietnam. The structures of Compounds 1-5 were elucidated by analysis of 1D and 2D NMR spectra and MS data. All the isolated compounds were evaluated for anti-proliferation activity and their suppression effects on receptor activator of nuclear factor B ligand (RANKL)-induced osteoclast differentiation using tartate-resisant acid phosphatase (TRAP). Compounds 1-5 had no anti-proliferative effect on human cancer cell lines up to 30 g/mL. Among these compounds, aspertetranone D (2) and wasabidienone E (4) exhibited weak osteoclast differentiation inhibitory activity at 10 g/mL. However, mactanamide (5) showed a potent suppression effect of osteoclast differentiation without any evidence of cytotoxicity.
ISSN
1660-3397
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/1038
DOI
10.3390/md16010014
Bibliographic Citation
MARINE DRUGS, v.16, no.1, 2018
Publisher
MDPI AG
Subject
NATURAL-PRODUCTS; DIFFERENTIATION; MICROBES; DERIVATIVES; RESORPTION; AGENTS
Keywords
mactanamide; osteoclastogenesis; marine fungus; Aspergillus flocculosus; TRAP assay
Type
Article
Language
English
Document Type
Article
Publisher
MDPI AG
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