Effects of waterborne copper on toxicity stress and apoptosis responses in red seabream, Pagrus major SCIE SCOPUS KCI

Cited 4 time in WEB OF SCIENCE Cited 4 time in Scopus
Title
Effects of waterborne copper on toxicity stress and apoptosis responses in red seabream, Pagrus major
Author(s)
Kim, Tae Hwan; Choi, Ji Yong; Jung, Min-Min; Oh, Sung-Yong; Choi, Cheol Young
KIOST Author(s)
Oh, Sung Yong(오승용)
Publication Year
2018-04
Abstract
Backgrounds: There has been an increasing trend of copper (Cu)-based aquaculture industry in the world, and it is necessary to evaluate the effect of copper ion exposure on water pollution. This study was aim to determine the critical concentration of toxic copper in adult red sea bream. Methods: Therefore, we investigated the effects of Cu toxicity on physiological stress and apoptosis exposed to various concentrations (10, 20, 30, and 40 mu g/L). We measured physiological stress-related (corticotrophin-releasing hormone, adrenocorticotropic hormone, cortisol, and glucose), other toxic stress-related (metallothionein and Na+/K+-ATPase), and apoptosis-related (caspase-3 and hydrogen peroxide) parameters. In addition, we confirmed apoptosis. Results: Physiological parameters were significantly increased from Cu concentration of 30 mu g/L or more. However, no significant differences were observed after exposures at 10 and 20 mu g/L. In addition, apoptotic cells were detected after exposure to 30 mu g/L. Conclusion: The results of this study indicate that high concentrations induce stress and apoptosis compared to normal conditions.
ISSN
1738-642X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/990
DOI
10.1007/s13273-018-0022-4
Bibliographic Citation
MOLECULAR & CELLULAR TOXICOLOGY, v.14, no.2, pp.201 - 210, 2018
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
Subject
TILAPIA OREOCHROMIS-MOSSAMBICUS; TROUT ONCORHYNCHUS-MYKISS; OXIDATIVE STRESS; RAINBOW-TROUT; CARASSIUS-AURATUS; PLASMA-CORTISOL; CHLORIDE CELLS; NA+/K+-ATPASE; FRESH-WATER; FISH
Keywords
Apoptosis; Copper; HPI axis; Physiological stress; Toxicity stress
Type
Article
Language
English
Document Type
Article
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
Related Researcher
Research Interests

Fish aquaculture,Aquacultural engineering,Environmental physiology,어류 양식,양식 공학,환경생리학

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