3-Chloro-4,5-dihydroxybenzaldehyde inhibits adipogenesis in 3T3-L1 adipocytes by regulating expression of adipogenic transcription factors and AMPK activation SCIE SCOPUS

Cited 4 time in WEB OF SCIENCE Cited 4 time in Scopus
Title
3-Chloro-4,5-dihydroxybenzaldehyde inhibits adipogenesis in 3T3-L1 adipocytes by regulating expression of adipogenic transcription factors and AMPK activation
Author(s)
Kang, Min-Cheol; Ding, Yuling; Kim, Junseong; Kim, Eun-A; Fernando, I. P. Shanura; Heo, Soo-Jin; Lee, Seung-Hong
KIOST Author(s)
Kim, Junseong(김준성)Kim, Eun A(김은아)Heo, Soo Jin(허수진)
Publication Year
2018-05-01
Abstract
Obesity is a serious health issue in many industrialized countries. It is a medical condition with excessive levels of fat accumulated in adipocytes. The objective of the present study was to determine the inhibitory effect of 3-chloro-4,5-dihydroxybenzaldehyde (CDB) on adipogenesis in 3T3-L1 adipocyte cells. CDB suppressed the differentiation and decreased lipid accumulation and triglycerides contents in 3T3-L1 adipocytes. Its suppression effect on fat accumulation was mediated via expression of adipogenesis factors (C/EBP alpha, SREBP-1c, PPAR gamma, and adiponectin) during adipocyte differentiation in white adipocyte cells. CDB's ability to suppress fat accumulation was increased in a concentration-dependent manner. It inhibited fatty acid synthesis related proteins including FAS, FABP4, leptin, and perilipin. It also increased expression of phosphorylated AMPK in adipocytes cells. These observations suggest that CDB has potential anti-obesity effect with ability to improve metabolic diseases.
ISSN
0009-2797
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/906
DOI
10.1016/j.cbi.2018.04.001
Bibliographic Citation
CHEMICO-BIOLOGICAL INTERACTIONS, v.287, pp.27 - 31, 2018
Publisher
ELSEVIER IRELAND LTD
Subject
HIGH-FAT DIET; PROTEIN-KINASE; LIVER-DISEASE; OBESITY; CELLS; CINNAMALDEHYDE; MICE; DIFFERENTIATION; ACCUMULATION; INFLAMMATION
Keywords
Adipogenesis; 3T3-L1; 3-Chloro-4,5-dihydroxybenzaldehyde; Anti-obesity; Adipocytes
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER IRELAND LTD
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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