Adverse effects and immune dysfunction in response to oral administration of weathered Iranian heavy crude oil in the rockfish Sebastes schlegeli SCIE SCOPUS

Cited 8 time in WEB OF SCIENCE Cited 9 time in Scopus
Title
Adverse effects and immune dysfunction in response to oral administration of weathered Iranian heavy crude oil in the rockfish Sebastes schlegeli
Author(s)
Lee, Eun-Hee; Kim, Moonkoo; Moon, Young-Sun; Yim, Un Hyuk; Ha, Sung Yong; Jeong, Chang-Bum; Lee, Jae-Seong; Jung, Jee-Hyun
KIOST Author(s)
Kim, Moon Koo(김문구)Yim, Un Hyuk(임운혁)Ha, Sung Yong(하성용)Jung, Jee Hyun(정지현)
Publication Year
2018-07
Abstract
To demonstrate the effects of weathered crude oil residue on the immune systems of resident fish, we measured the changes in toxic chemical concentrations, apoptosis, phagocytosis, metabolism, immune-related gene expression, and cell cycle arrest in livers or kidneys for up to 96 h after the weathered Iranian heavy crude oil (WIHCO) exposure by oral gavage in juvenile rockfish Sebastes schlegeli. Parent polyaromatic hydrocarbons (PAHs) in livers increased up to 5590 ng/g after 6 h exposure and then declined rapidly within 24 h. Hepatodetoxification and immune-related gene expression were also significantly increased (P < 0.05) after 6 h exposure and then declined rapidly within 24 h. However, biliary PAH metabolites and EROD activity remained elevated throughout the test period. Flow cytometry analysis also indicated sustained apoptosis and cell cycle arrests with reduced phagocytic activity for 96 h. Taken together, these results demonstrate rapid declination of the parent PAHs, whereas PAH metabolites remained much longer in tissues with prolonged suppression of immunity in molecular and cellular level, suggesting that weathered crude oil residue is likely linked to the high incidence of immune dysfunction in residential rockfish in oil spill area.
ISSN
0166-445X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/870
DOI
10.1016/j.aquatox.2018.04.010
Bibliographic Citation
AQUATIC TOXICOLOGY, v.200, pp.127 - 135, 2018
Publisher
ELSEVIER SCIENCE BV
Subject
EXXON-VALDEZ-OIL; TOXIC-CHEMICALS; FUEL-OIL; SPILL; BIOMARKERS; BIOTRANSFORMATION; CONTAMINATION; EXPRESSION; APOPTOSIS; BACTERIAL
Keywords
Oil spill; Immune system; PAHs; Apoptosis; Flow cytometry; Phagocytosis
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER SCIENCE BV
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