Plasma biomarkers in juvenile marine fish provide evidence for endocrine modulation potential of organotin compounds SCIE SCOPUS

Cited 8 time in WEB OF SCIENCE Cited 9 time in Scopus
Title
Plasma biomarkers in juvenile marine fish provide evidence for endocrine modulation potential of organotin compounds
Author(s)
Min, Byung Hwa; Kim, Bo-Mi; Kim, Moonkoo; Kang, Jung-Hoon; Jung, Jee-Hyun; Rhee, Jae-Sung
KIOST Author(s)
Kim, Moon Koo(김문구)Kang, Jung Hoon(강정훈)Jung, Jee Hyun(정지현)
Publication Year
2018-08
Abstract
Organotin compounds, such as tributyltin (TBT) and triphenyltin (TPT), have been widely used to control marine fouling. Here, we show that organotin stimulation reduces the hormone levels in the plasma of two economically important aquaculture fish. Blood plasma samples were collected from juvenile red seabream and black rockfish exposed to environmentally realistic concentrations of TBT and TPT for 14 days. The levels of two plasma biomarkers, namely the yolk protein precursor vitellogenin (VTG) and the sex steroid 17 beta-estradiol (E2), were measured to determine the endocrine disrupting potential of the organotin compounds. Both organotin compounds were dose-dependently accumulated in the blood of two fish. Exposure to waterborne TBT and TBT significantly decreased the plasma VTG levels in both the juvenile fish in a dose-dependent manner. In contrast, the treatment with E2, a well-known VTG inducer, significantly increased the plasma VTG levels in both the fish. In addition, the mRNA levels of vtg were also downregulated in the liver tissues of both the fish at 100 and/or 1000 ng L-1 of TBT or TPT exposure. The plasma E2 titers were significantly suppressed at 100 and/or 1000 ng L-1 of TBT or TPT exposure for 14 days compared to their titer in the control. Since estrogen directly regulates vtg gene expression and VTG synthesis, our results reveal the endocrine disrupting potential of organotin compounds, and subsequently the endocrine modulation at early stage of fish can trigger further fluctuations in sexual differentiation, maturation, sex ration or egg production. In addition, the results demonstrate their effects on non-target organisms, particularly on animals reared in aquaculture and fisheries.
ISSN
1532-0456
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/858
DOI
10.1016/j.cbpc.2018.05.001
Bibliographic Citation
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v.210, pp.35 - 43, 2018
Publisher
ELSEVIER SCIENCE INC
Subject
GENE-EXPRESSION; MESSENGER-RNA; EXTRAHEPATIC EXPRESSION; VITELLOGENIN INDUCTION; ENVIRONMENTAL LEVELS; SEX-DIFFERENTIATION; AROMATASE-ACTIVITY; RISK-ASSESSMENT; ACUTE TOXICITY; FOOD-WEB
Keywords
Marine fish; Plasma biomarker; Tributyltin; Triphenyltin; Vitellogenin; 17 beta-estradiol
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER SCIENCE INC
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