Plasma biomarkers in juvenile marine fish provide evidence for endocrine modulation potential of organotin compounds
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Title
- Plasma biomarkers in juvenile marine fish provide evidence for endocrine modulation potential of organotin compounds
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Author(s)
- Min, Byung Hwa; Kim, Bo-Mi; Kim, Moonkoo; Kang, Jung-Hoon; Jung, Jee-Hyun; Rhee, Jae-Sung
- KIOST Author(s)
- Kim, Moon Koo(김문구); Kang, Jung Hoon(강정훈); Jung, Jee Hyun(정지현)
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Alternative Author(s)
- 김문구; 강정훈; 정지현
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Publication Year
- 2018-08
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Abstract
- Organotin compounds, such as tributyltin (TBT) and triphenyltin (TPT), have been widely used to control marine fouling. Here, we show that organotin stimulation reduces the hormone levels in the plasma of two economically important aquaculture fish. Blood plasma samples were collected from juvenile red seabream and black rockfish exposed to environmentally realistic concentrations of TBT and TPT for 14 days. The levels of two plasma biomarkers, namely the yolk protein precursor vitellogenin (VTG) and the sex steroid 17 beta-estradiol (E2), were measured to determine the endocrine disrupting potential of the organotin compounds. Both organotin compounds were dose-dependently accumulated in the blood of two fish. Exposure to waterborne TBT and TBT significantly decreased the plasma VTG levels in both the juvenile fish in a dose-dependent manner. In contrast, the treatment with E2, a well-known VTG inducer, significantly increased the plasma VTG levels in both the fish. In addition, the mRNA levels of vtg were also downregulated in the liver tissues of both the fish at 100 and/or 1000 ng L-1 of TBT or TPT exposure. The plasma E2 titers were significantly suppressed at 100 and/or 1000 ng L-1 of TBT or TPT exposure for 14 days compared to their titer in the control. Since estrogen directly regulates vtg gene expression and VTG synthesis, our results reveal the endocrine disrupting potential of organotin compounds, and subsequently the endocrine modulation at early stage of fish can trigger further fluctuations in sexual differentiation, maturation, sex ration or egg production. In addition, the results demonstrate their effects on non-target organisms, particularly on animals reared in aquaculture and fisheries.
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ISSN
- 1532-0456
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/858
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DOI
- 10.1016/j.cbpc.2018.05.001
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Bibliographic Citation
- COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v.210, pp.35 - 43, 2018
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Publisher
- ELSEVIER SCIENCE INC
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Subject
- GENE-EXPRESSION; MESSENGER-RNA; EXTRAHEPATIC EXPRESSION; VITELLOGENIN INDUCTION; ENVIRONMENTAL LEVELS; SEX-DIFFERENTIATION; AROMATASE-ACTIVITY; RISK-ASSESSMENT; ACUTE TOXICITY; FOOD-WEB
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Keywords
- Marine fish; Plasma biomarker; Tributyltin; Triphenyltin; Vitellogenin; 17 beta-estradiol
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Type
- Article
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Language
- English
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Document Type
- Article
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