Antimalarial activity of the isolates from the marine sponge Hyrtios erectus against the chloroquine-resistant Dd2 strain of Plasmodium falciparum SCIE SCOPUS

Cited 8 time in WEB OF SCIENCE Cited 9 time in Scopus
Title
Antimalarial activity of the isolates from the marine sponge Hyrtios erectus against the chloroquine-resistant Dd2 strain of Plasmodium falciparum
Author(s)
Ju, Eunsin; Latif, Abdul; Kong, Chang-Suk; Seo, Youngwan; Lee, Yeon-Ju; Dalal, Seema R.; Cassera, Maria B.; Kingston, David G. I.
KIOST Author(s)
Lee, Yeon Ju(이연주)
Publication Year
2018-09
Abstract
This work reports the isolation of the three known compounds, smenotronic acid (1), ilimaquinone (2), and pelorol (3), from the 85% methanol (MeOH)-soluble fraction of the sponge Hyrtios erectus. The structures of the isolated compounds were determined with the help of modern spectroscopic techniques, and the resulting compounds were then subjected to in vitro screening to determine their antimalarial potential against the chloroquine-resistant Dd2 strain of Plasmodium falciparum. Amongst the three compounds, pelorol (3) showed significant activity against P. falciparum with an IC50 value of 0.8 mu M. For smenotronic acid (1) and ilimaquinone (2), moderate activities were observed with IC50 values of 3.51 and 2.11 mu M, respectively.
ISSN
0939-5075
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/840
DOI
10.1515/znc-2018-0025
Bibliographic Citation
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, v.73, no.9-10, pp.397 - 400, 2018
Publisher
WALTER DE GRUYTER GMBH
Subject
ILIMAQUINONE; QUINONE
Keywords
antimalarial activity; Hyrtios erectus; ilimaquinone; pelorol; smenotronic acid
Type
Article
Language
English
Document Type
Article
Publisher
WALTER DE GRUYTER GMBH
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