Nonylphenol induces mortality and reduces hatching rate through increase of oxidative stress and dysfunction of antioxidant defense system in marine medaka embryo SCIE SCOPUS KCI

Cited 10 time in WEB OF SCIENCE Cited 10 time in Scopus
Title
Nonylphenol induces mortality and reduces hatching rate through increase of oxidative stress and dysfunction of antioxidant defense system in marine medaka embryo
Author(s)
Lee, Do-Hee; Jo, Ye Jin; Eom, Hye-Jin; Yum, Seungshic; Rhee, Jae-Sung
KIOST Author(s)
Jo, Yejin(조예진)Yum, Seungshic(염승식)
Publication Year
2018-10
Abstract
BackgroundsNonylphenol (NP) is a hydrophobic xenobiotic compound classified as an endocrine disrupting chemical (EDC) and accumulates in environmental compartments owing to its extensive use. In this study, the detrimental effects of 4-nonylphenol (4-NP) were investigated in marine medaka (Oryzias javanicus) embryos and novel insights into their toxicities are provided.MethodsFollowing exposure to different concentrations of 4-NP (200-1000 g/L), the mortality, hatching rate, and survival rate of larvae were measured. Biochemical endpoints, including intracellular oxidative stress, apoptosis, antioxidant defense, and vitellogenin level, were analyzed to assess the toxicity and endocrine disrupting potential of 4-NP.Results4-NP treatment during post fertilization reduced hatching rate in a dose-dependent manner. Exposure to waterborne 4-NP induced oxidative stress and dysfunction of antioxidant defense systems, which led to apoptotic cellular death. In hatched larvae, the survival rate decreased as vitellegenin level with increasing exposure concentrations owing to persistent 4-NP.ConclusionOur study provides evidence of cellular stress induction/toxicity caused by 4-NP and endocrine disrupting potential in marine medaka embryos.
ISSN
1738-642X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/827
DOI
10.1007/s13273-018-0048-7
Bibliographic Citation
MOLECULAR & CELLULAR TOXICOLOGY, v.14, no.4, pp.437 - 444, 2018
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
Subject
TROUT ONCORHYNCHUS-MYKISS; JUVENILE RAINBOW-TROUT; ZEBRAFISH DANIO-RERIO; SALMON SALMO-SALAR; MOLECULAR RESPONSES; ALKYLPHENOLIC COMPOUNDS; VITELLOGENIN SYNTHESIS; ORYZIAS-MELASTIGMA; EXPOSURE; 17-BETA-ESTRADIOL
Keywords
Marine medaka; 4-Nonylphenol; Toxicity; Embryo; Larvae
Type
Article
Language
English
Document Type
Article
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
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