Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Kim, E.-A. | - |
dc.contributor.author | Kim, S.-Y. | - |
dc.contributor.author | Kim, J. | - |
dc.contributor.author | Oh, J.-Y. | - |
dc.contributor.author | Kim, H.-S. | - |
dc.contributor.author | Yoon, W.-J. | - |
dc.contributor.author | Kang, D.-H. | - |
dc.contributor.author | Heo, S.-J. | - |
dc.date.accessioned | 2020-04-16T08:25:25Z | - |
dc.date.available | 2020-04-16T08:25:25Z | - |
dc.date.created | 2020-01-28 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/771 | - |
dc.description.abstract | Brown algae are known to contain rich anti-inflammatory compounds. The objective of this study was to identify anti-inflammatory compound in the Sargassum macrocarpum and anti-inflammatory effect of tuberatolide B (TTB) was investigated. TTB significantly suppressed the production of NO and pro-inflammatory cytokines such as interleukin (IL)-6 and IL-1β. In addition, the mechanism involved in the inhibition of the inflammatory effect of LPS by TTB was investigated. The results showed that TTB aforementioned this effect through NF-κB and MAPKs phosphorylation pathways. We also assessed the anti-inflammatory activity of TTB using in vivo zebrafish model. In LPS-stimulated zebrafish, TTB enhanced survival and significantly inhibited the NO production and mRNA expression of inducible NO synthase. Therefore, anti-inflammatory activity of TTB against LPS in RAW264.7 cells and the zebrafish model was determined. These finding suggest that TTB may be used as functional anti-inflammatory foods and nutraceuticals. © 2018 Elsevier Ltd | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model | - |
dc.type | Article | - |
dc.citation.endPage | 115 | - |
dc.citation.startPage | 109 | - |
dc.citation.title | Journal of Functional Foods | - |
dc.citation.volume | 52 | - |
dc.contributor.alternativeName | 김은아 | - |
dc.contributor.alternativeName | 김준성 | - |
dc.contributor.alternativeName | 강도형 | - |
dc.contributor.alternativeName | 허수진 | - |
dc.identifier.bibliographicCitation | Journal of Functional Foods, v.52, pp.109 - 115 | - |
dc.identifier.doi | 10.1016/j.jff.2018.10.030 | - |
dc.identifier.scopusid | 2-s2.0-85055886994 | - |
dc.identifier.wosid | 000455691800013 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | PROMOTES NEURITE OUTGROWTH | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY ACTIVITY | - |
dc.subject.keywordPlus | ECKLONIA-CAVA | - |
dc.subject.keywordPlus | NO PRODUCTION | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | MEROTERPENOIDS | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | PHEOPHYTIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Sargassum macrocarpum | - |
dc.subject.keywordAuthor | Tuberatolide B | - |
dc.subject.keywordAuthor | Zebrafish | - |
dc.subject.keywordAuthor | Anti-inflammatory | - |
dc.subject.keywordAuthor | RAW264.7 cells | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |