Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model SCIE SCOPUS

DC Field Value Language
dc.contributor.author Kim, E.-A. -
dc.contributor.author Kim, S.-Y. -
dc.contributor.author Kim, J. -
dc.contributor.author Oh, J.-Y. -
dc.contributor.author Kim, H.-S. -
dc.contributor.author Yoon, W.-J. -
dc.contributor.author Kang, D.-H. -
dc.contributor.author Heo, S.-J. -
dc.date.accessioned 2020-04-16T08:25:25Z -
dc.date.available 2020-04-16T08:25:25Z -
dc.date.created 2020-01-28 -
dc.date.issued 2019-01 -
dc.identifier.issn 1756-4646 -
dc.identifier.uri https://sciwatch.kiost.ac.kr/handle/2020.kiost/771 -
dc.description.abstract Brown algae are known to contain rich anti-inflammatory compounds. The objective of this study was to identify anti-inflammatory compound in the Sargassum macrocarpum and anti-inflammatory effect of tuberatolide B (TTB) was investigated. TTB significantly suppressed the production of NO and pro-inflammatory cytokines such as interleukin (IL)-6 and IL-1β. In addition, the mechanism involved in the inhibition of the inflammatory effect of LPS by TTB was investigated. The results showed that TTB aforementioned this effect through NF-κB and MAPKs phosphorylation pathways. We also assessed the anti-inflammatory activity of TTB using in vivo zebrafish model. In LPS-stimulated zebrafish, TTB enhanced survival and significantly inhibited the NO production and mRNA expression of inducible NO synthase. Therefore, anti-inflammatory activity of TTB against LPS in RAW264.7 cells and the zebrafish model was determined. These finding suggest that TTB may be used as functional anti-inflammatory foods and nutraceuticals. © 2018 Elsevier Ltd -
dc.description.uri 1 -
dc.language English -
dc.publisher Elsevier Ltd -
dc.title Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model -
dc.type Article -
dc.citation.endPage 115 -
dc.citation.startPage 109 -
dc.citation.title Journal of Functional Foods -
dc.citation.volume 52 -
dc.contributor.alternativeName 김은아 -
dc.contributor.alternativeName 김준성 -
dc.contributor.alternativeName 강도형 -
dc.contributor.alternativeName 허수진 -
dc.identifier.bibliographicCitation Journal of Functional Foods, v.52, pp.109 - 115 -
dc.identifier.doi 10.1016/j.jff.2018.10.030 -
dc.identifier.scopusid 2-s2.0-85055886994 -
dc.identifier.wosid 000455691800013 -
dc.type.docType Article -
dc.description.journalClass 1 -
dc.description.isOpenAccess N -
dc.subject.keywordPlus PROMOTES NEURITE OUTGROWTH -
dc.subject.keywordPlus ANTIINFLAMMATORY ACTIVITY -
dc.subject.keywordPlus ECKLONIA-CAVA -
dc.subject.keywordPlus NO PRODUCTION -
dc.subject.keywordPlus ACID -
dc.subject.keywordPlus LIPOPOLYSACCHARIDE -
dc.subject.keywordPlus MEROTERPENOIDS -
dc.subject.keywordPlus ANTIOXIDANT -
dc.subject.keywordPlus PHEOPHYTIN -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordAuthor Sargassum macrocarpum -
dc.subject.keywordAuthor Tuberatolide B -
dc.subject.keywordAuthor Zebrafish -
dc.subject.keywordAuthor Anti-inflammatory -
dc.subject.keywordAuthor RAW264.7 cells -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
Appears in Collections:
Jeju Research Institute > Jeju Bio Research Center > 1. Journal Articles
Jeju Research Institute > Tropical & Subtropical Research Center > 1. Journal Articles
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