Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model SCIE SCOPUS

Cited 14 time in WEB OF SCIENCE Cited 14 time in Scopus
Title
Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model
Author(s)
Kim, E.-A.; Kim, S.-Y.; Kim, J.; Oh, J.-Y.; Kim, H.-S.; Yoon, W.-J.; Kang, D.-H.; Heo, S.-J.
KIOST Author(s)
Kim, Eun A(김은아)Kim, Junseong(김준성)Kang, Do-Hyung(강도형)Heo, Soo Jin(허수진)
Publication Year
2019-01
Abstract
Brown algae are known to contain rich anti-inflammatory compounds. The objective of this study was to identify anti-inflammatory compound in the Sargassum macrocarpum and anti-inflammatory effect of tuberatolide B (TTB) was investigated. TTB significantly suppressed the production of NO and pro-inflammatory cytokines such as interleukin (IL)-6 and IL-1β. In addition, the mechanism involved in the inhibition of the inflammatory effect of LPS by TTB was investigated. The results showed that TTB aforementioned this effect through NF-κB and MAPKs phosphorylation pathways. We also assessed the anti-inflammatory activity of TTB using in vivo zebrafish model. In LPS-stimulated zebrafish, TTB enhanced survival and significantly inhibited the NO production and mRNA expression of inducible NO synthase. Therefore, anti-inflammatory activity of TTB against LPS in RAW264.7 cells and the zebrafish model was determined. These finding suggest that TTB may be used as functional anti-inflammatory foods and nutraceuticals. © 2018 Elsevier Ltd
ISSN
1756-4646
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/771
DOI
10.1016/j.jff.2018.10.030
Bibliographic Citation
Journal of Functional Foods, v.52, pp.109 - 115, 2019
Publisher
Elsevier Ltd
Keywords
Anti-inflammatory; RAW264.7 cells; Sargassum macrocarpum; Tuberatolide B; Zebrafish
Type
Article
Language
English
Document Type
Article
Publisher
Elsevier Ltd
Related Researcher
Research Interests

Marine Life Science,Marine Natural Products,Bioactivities,해양생명과학,해양천연물학,생리활성

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