Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model
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Title
- Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model
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Author(s)
- Kim, E.-A.; Kim, S.-Y.; Kim, J.; Oh, J.-Y.; Kim, H.-S.; Yoon, W.-J.; Kang, D.-H.; Heo, S.-J.
- KIOST Author(s)
- Kim, Eun A(김은아); Kim, Jun Seong(김준성); Kang, Do Hyung(강도형); Heo, Soo Jin(허수진)
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Alternative Author(s)
- 김은아; 김준성; 강도형; 허수진
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Publication Year
- 2019-01
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Abstract
- Brown algae are known to contain rich anti-inflammatory compounds. The objective of this study was to identify anti-inflammatory compound in the Sargassum macrocarpum and anti-inflammatory effect of tuberatolide B (TTB) was investigated. TTB significantly suppressed the production of NO and pro-inflammatory cytokines such as interleukin (IL)-6 and IL-1β. In addition, the mechanism involved in the inhibition of the inflammatory effect of LPS by TTB was investigated. The results showed that TTB aforementioned this effect through NF-κB and MAPKs phosphorylation pathways. We also assessed the anti-inflammatory activity of TTB using in vivo zebrafish model. In LPS-stimulated zebrafish, TTB enhanced survival and significantly inhibited the NO production and mRNA expression of inducible NO synthase. Therefore, anti-inflammatory activity of TTB against LPS in RAW264.7 cells and the zebrafish model was determined. These finding suggest that TTB may be used as functional anti-inflammatory foods and nutraceuticals. © 2018 Elsevier Ltd
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ISSN
- 1756-4646
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/771
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DOI
- 10.1016/j.jff.2018.10.030
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Bibliographic Citation
- Journal of Functional Foods, v.52, pp.109 - 115, 2019
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Publisher
- Elsevier Ltd
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Keywords
- Sargassum macrocarpum; Tuberatolide B; Zebrafish; Anti-inflammatory; RAW264.7 cells
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Type
- Article
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Language
- English
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Document Type
- Article
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