Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp. SCIE SCOPUS

Cited 9 time in WEB OF SCIENCE Cited 10 time in Scopus
Title
Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp.
Author(s)
Lee, Yeon-Ju; Kim, Su Hyun; Choi, Hansol; Lee, Hyi-Seung; Lee, Jong Seok; Shin, Hee Jae; Lee, Jihoon
KIOST Author(s)
Lee, Yeon Ju(이연주)Lee, Hyi Seung(이희승)Lee, Jong Seok(이종석)Shin, Hee Jae(신희재)Lee, Ji Hoon(이지훈)
Alternative Author(s)
이연주; 최한솔; 이희승; 이종석; 신희재; 이지훈
Publication Year
2019-03-01
Abstract
Three furan-containing scalarane sesterterpenoids (1-3) and a novel pyrrole-containing analog (4) were isolated from the sponge Scalarispongia species. Compound 3, reported in the literature as a synthetic derivative of furoscalarol 2, was for the first time isolated from a natural source. During the separation performed using a silica column in the presence of methanol, 16-methoxy derivatives (5, 6) were obtained from the unintended reaction of 2. The isolated natural products 3 and 4 and the artifact 5 showed moderate to high cytotoxicity against six human cancer cell lines, whereas compound 6, the C-16 epimer of 5, showed no cytotoxicity at a concentration of 60 mu M.
ISSN
1420-3049
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/667
DOI
10.3390/molecules24050840
Bibliographic Citation
MOLECULES, v.24, no.5, 2019
Publisher
MDPI
Subject
MARINE SPONGE; METABOLITES; INHIBITORS
Keywords
Scalarispongia; sesterterpenoid; furan; pyrrole; conjugate addition; cytotoxicity
Type
Article
Language
English
Document Type
Article
Publisher
MDPI
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