Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp.
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Title
- Cytotoxic Furan- and Pyrrole-Containing Scalarane Sesterterpenoids Isolated from the Sponge Scalarispongia sp.
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Author(s)
- Lee, Yeon-Ju; Kim, Su Hyun; Choi, Hansol; Lee, Hyi-Seung; Lee, Jong Seok; Shin, Hee Jae; Lee, Jihoon
- KIOST Author(s)
- Lee, Yeon Ju(이연주); Lee, Hyi Seung(이희승); Lee, Jong Seok(이종석); Shin, Hee Jae(신희재); Lee, Ji Hoon(이지훈)
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Alternative Author(s)
- 이연주; 최한솔; 이희승; 이종석; 신희재; 이지훈
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Publication Year
- 2019-03-01
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Abstract
- Three furan-containing scalarane sesterterpenoids (1-3) and a novel pyrrole-containing analog (4) were isolated from the sponge Scalarispongia species. Compound 3, reported in the literature as a synthetic derivative of furoscalarol 2, was for the first time isolated from a natural source. During the separation performed using a silica column in the presence of methanol, 16-methoxy derivatives (5, 6) were obtained from the unintended reaction of 2. The isolated natural products 3 and 4 and the artifact 5 showed moderate to high cytotoxicity against six human cancer cell lines, whereas compound 6, the C-16 epimer of 5, showed no cytotoxicity at a concentration of 60 mu M.
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ISSN
- 1420-3049
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/667
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DOI
- 10.3390/molecules24050840
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Bibliographic Citation
- MOLECULES, v.24, no.5, 2019
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Publisher
- MDPI
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Subject
- MARINE SPONGE; METABOLITES; INHIBITORS
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Keywords
- Scalarispongia; sesterterpenoid; furan; pyrrole; conjugate addition; cytotoxicity
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Type
- Article
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Language
- English
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Document Type
- Article
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