Increased Anti-Inflammatory Effects on LPS-Induced Microglia Cells by Spirulina maxima Extract from Ultrasonic Process SCIE SCOPUS
DC Field | Value | Language |
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dc.contributor.author | Choi, Woon Yong | - |
dc.contributor.author | Sim, Jae-Hun | - |
dc.contributor.author | Lee, Jung-Youl | - |
dc.contributor.author | Kang, Do Hyung | - |
dc.contributor.author | Lee, Hyeon Yong | - |
dc.date.accessioned | 2020-04-16T08:15:11Z | - |
dc.date.available | 2020-04-16T08:15:11Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/639 | - |
dc.description.abstract | The Spirulina maxima exact from a non-thermal ultrasonic process (UE) contains 17.5 mg/g of total chlorophyll, compared to 6.24 mg/g of chlorophyll derived from the conventional 70% ethanol extraction at 80 degrees C for 12 h (EE). The UE also showed relatively low cytotoxicity against murine microglial cells (BV-2) and inhibited the production of the inflammatory mediators, NO and PGE(2). The UE also effectively suppresses both mRNA expression and the production of pro-inflammatory cytokines, such as TNF-alpha, IL-6 and IL-1 beta, in a concentration-dependent manner. Notably, TNF-alpha gene and protein production were most strongly down-regulated, while IL-6 was the least affected by all ranges of treatment concentrations. This work first demonstrated a quantitative correlation between mRNA expression and the production of cytokines, showing that suppression of TNF-alpha gene expression was most significantly correlated with its secretion. These results clearly proved that the anti-inflammatory effects of Spirulina extract from a nonthermal ultrasonic process, which yielded high concentrations of intact forms of chlorophylls, were increased two-fold compared to those of conventional extracts processed at high temperature. | - |
dc.description.uri | 1 | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Increased Anti-Inflammatory Effects on LPS-Induced Microglia Cells by Spirulina maxima Extract from Ultrasonic Process | - |
dc.type | Article | - |
dc.citation.title | APPLIED SCIENCES-BASEL | - |
dc.citation.volume | 9 | - |
dc.citation.number | 10 | - |
dc.contributor.alternativeName | 강도형 | - |
dc.identifier.bibliographicCitation | APPLIED SCIENCES-BASEL, v.9, no.10 | - |
dc.identifier.doi | 10.3390/app9102144 | - |
dc.identifier.scopusid | 2-s2.0-85066607198 | - |
dc.identifier.wosid | 000473748100179 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | BERBERINE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ANTIOXIDANTS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | SUPPRESSES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MICROALGAE | - |
dc.subject.keywordPlus | MEDIATORS | - |
dc.subject.keywordAuthor | Spirulina maxima | - |
dc.subject.keywordAuthor | anti-inflammatory effects | - |
dc.subject.keywordAuthor | neuroproective activities | - |
dc.subject.keywordAuthor | ultrasonic extraction process | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |