Petrocortynes and petrosiacetylenes, novel polyacetylenes from a sponge of the genus Petrosia SCIE SCOPUS

Cited 48 time in WEB OF SCIENCE Cited 49 time in Scopus
Title
Petrocortynes and petrosiacetylenes, novel polyacetylenes from a sponge of the genus Petrosia
Author(s)
Seo, Y; Cho, KW; Rho, JR; Shin, J; Sim, CJ
Alternative Author(s)
서영완; 조기웅; 노정래; 신종헌
Publication Year
1998-01-15
Abstract
Petrocortynes A-C (1-3) and petrosiacetylenes A-D (4-7), novel long-chain polyacetylenes and related metabolites have been isolated from a sponge of the genus Petrosia. Compounds 1 and 2 are C-46 linear tetraacetylenes structurally related to petroformynes while 3 possesses an unusual gamma-pyrone ring formed by an oxidative cyclization of a diacetylenic carbinol functionality. Compounds 4-7 are highly symmetric C-30 linear polyacetylenes in that 6 and 7 were isolated as unseparable mixtures of diastereomers. The structures of these compounds have been elucidated by combined chemical and spectral methods. Absolute stereochemistry has been determined by the modified Mosher's method. These compounds exhibited significant brine-shrimp lethality, RNA-cleaving activity, and/or moderate inhibitory activity against PLA(2) and Na+/K+ ATPase. (C) 1997 Elsevier Science Ltd. All rights reserved.
ISSN
0040-4020
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/6269
DOI
10.1016/S0040-4020(97)10290-3
Bibliographic Citation
TETRAHEDRON, v.54, no.3-4, pp.447 - 462, 1998
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
BIOACTIVE MARINE METABOLITES; ABSOLUTE-CONFIGURATION; STEREOCHEMISTRY; FICIFORMIS; CRIBROCHALINA; PETROFORMYNES; VASCULUM; ACID
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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