Osirisynes A-F, highly oxygenated polyacetylenes from the sponge Haliclona osiris

Abstract

Osirisynes A-F(1-6), highly oxygenated C-47 polyacetylenes have been isolated from the sponge Haliclona osiris collected from Guam. These compounds possess a diacetylenic carbinol and an a-acetylenic carboxylic acid as common structural features. The structures of osirisynes have been determined by combined spectroscopic methods. These compounds exhibited moderate cytotoxicity and inhibitory activities against Na+/K+-ATPase and reverse transcriptase (RT). (C) 1998 Elsevier Science Ltd. All rights reserved.