Five new polyacetylenes from a sponge of the genus Petrosia
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Title
- Five new polyacetylenes from a sponge of the genus Petrosia
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Author(s)
- Shin, J; Seo, Y; Cho, KW
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Alternative Author(s)
- 신종헌; 서영완; 조기웅
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Publication Year
- 1998-10
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Abstract
- Petrocortynes D-H, novel C-46 polyacetylenes, were isolated from a sponge of the genus Petrosia collected from Keomun Island, Korea. Petrocortyne D (2) is a 4,5-dihydro derivative of a diastereomer of petrocortyne A (1), and petrocortynes E-H (3-6) possess an additional allylic-hydroxyl group. The structures of these compounds were determined by combined chemical and spectral methods, and absolute configurations of most of the asymmetric carbon centers were determined by the modified Mosher's method. Limitations on the application of Mosher's method to allylic alcohols is discussed. Petrocortynes D-H exhibited moderate cytotoxicity and inhibitory activity against PLA(2).
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ISSN
- 0163-3864
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/6247
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DOI
- 10.1021/np9802015
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Bibliographic Citation
- JOURNAL OF NATURAL PRODUCTS, v.61, no.10, pp.1268 - 1273, 1998
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Publisher
- AMER CHEMICAL SOC
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Subject
- BIOACTIVE MARINE METABOLITES; ABSOLUTE-CONFIGURATION; CALLYSPONGIA-TRUNCATA; NATURAL-PRODUCTS; FICIFORMIS; STEREOCHEMISTRY; PETROFORMYNES; INHIBITORS; ACID
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Type
- Article
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Language
- English
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Document Type
- Article
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