Five new polyacetylenes from a sponge of the genus Petrosia SCIE SCOPUS

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Title
Five new polyacetylenes from a sponge of the genus Petrosia
Author(s)
Shin, J; Seo, Y; Cho, KW
Alternative Author(s)
신종헌; 서영완; 조기웅
Publication Year
1998-10
Abstract
Petrocortynes D-H, novel C-46 polyacetylenes, were isolated from a sponge of the genus Petrosia collected from Keomun Island, Korea. Petrocortyne D (2) is a 4,5-dihydro derivative of a diastereomer of petrocortyne A (1), and petrocortynes E-H (3-6) possess an additional allylic-hydroxyl group. The structures of these compounds were determined by combined chemical and spectral methods, and absolute configurations of most of the asymmetric carbon centers were determined by the modified Mosher's method. Limitations on the application of Mosher's method to allylic alcohols is discussed. Petrocortynes D-H exhibited moderate cytotoxicity and inhibitory activity against PLA(2).
ISSN
0163-3864
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/6247
DOI
10.1021/np9802015
Bibliographic Citation
JOURNAL OF NATURAL PRODUCTS, v.61, no.10, pp.1268 - 1273, 1998
Publisher
AMER CHEMICAL SOC
Subject
BIOACTIVE MARINE METABOLITES; ABSOLUTE-CONFIGURATION; CALLYSPONGIA-TRUNCATA; NATURAL-PRODUCTS; FICIFORMIS; STEREOCHEMISTRY; PETROFORMYNES; INHIBITORS; ACID
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
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