Gagunins, highly oxygenated diterpenoids from the sponge Phorbas sp.
SCIE
SCOPUS
Cited 32 time in
WEB OF SCIENCE
Cited 32 time in
Scopus
-
Title
- Gagunins, highly oxygenated diterpenoids from the sponge Phorbas sp.
-
Author(s)
- Rho, JR; Lee, HS; Sim, CJ; Shin, J
- KIOST Author(s)
- Lee, Hyi Seung(이희승)
-
Alternative Author(s)
- 노정래; 이희승
-
Publication Year
- 2002-11-18
-
Abstract
- Gagunins A-G, seven new diterpenoids were isolated from the sponge Phorbas sp. collected from Gagu-Do, Korea. The carbon skeleton of these highly oxygenated metabolites was determined to be an unusual 10,13-bis-epi-homoverrucosane on the basis of combined chemical and spectral methods. Stereochemical assignments of these diterpenoids were accomplished by extensive ROESY and 1D NOESY experiments. The novel compounds exhibited significant cytotoxicity with values ranging from 0.03 to 51 mug/mL, toward a human leukemia cell-line (K-562). (C) 2002 Elsevier Science Ltd. All rights reserved.
-
ISSN
- 0040-4020
-
URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/5644
-
DOI
- 10.1016/S0040-4020(02)01257-7
-
Bibliographic Citation
- TETRAHEDRON, v.58, no.47, pp.9585 - 9591, 2002
-
Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
-
Subject
- VERRUCOSANE DITERPENOIDS; LIVERWORT
-
Keywords
- marine metabolites; sponge; 10,13-bis-epi-homoverrucosane; cytotoxicity
-
Type
- Article
-
Language
- English
-
Document Type
- Article
- Files in This Item:
-
There are no files associated with this item.
Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.