Gagunins, highly oxygenated diterpenoids from the sponge Phorbas sp. SCIE SCOPUS

Cited 27 time in WEB OF SCIENCE Cited 27 time in Scopus
Title
Gagunins, highly oxygenated diterpenoids from the sponge Phorbas sp.
Author(s)
Rho, JR; Lee, HS; Sim, CJ; Shin, J
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2002-11-18
Abstract
Gagunins A-G, seven new diterpenoids were isolated from the sponge Phorbas sp. collected from Gagu-Do, Korea. The carbon skeleton of these highly oxygenated metabolites was determined to be an unusual 10,13-bis-epi-homoverrucosane on the basis of combined chemical and spectral methods. Stereochemical assignments of these diterpenoids were accomplished by extensive ROESY and 1D NOESY experiments. The novel compounds exhibited significant cytotoxicity with values ranging from 0.03 to 51 mug/mL, toward a human leukemia cell-line (K-562). (C) 2002 Elsevier Science Ltd. All rights reserved.
ISSN
0040-4020
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/5644
DOI
10.1016/S0040-4020(02)01257-7
Bibliographic Citation
TETRAHEDRON, v.58, no.47, pp.9585 - 9591, 2002
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
VERRUCOSANE DITERPENOIDS; LIVERWORT
Keywords
marine metabolites; sponge; 10,13-bis-epi-homoverrucosane; cytotoxicity
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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