노닐페놀을 주사한 조피볼락의 신장 MFO (mixed function oxidase)의 반응 KCI

Title
노닐페놀을 주사한 조피볼락의 신장 MFO (mixed function oxidase)의 반응
Alternative Title
Responses of Renal Mixed Function Oxidase System in Rockfish (Sebastes schlegeli) Administered with 4-Nonylphenol
Author(s)
전중균; 이지선; 손영창; 홍경표; 심원준; 김병기; 한창희
KIOST Author(s)
Shim, Won Joon(심원준)
Alternative Author(s)
홍경표; 심원준
Publication Year
2003-12
Abstract
Effects of 4-nonylphenol (4-NP) on mixed function oxygenase (MFO) in the kidneies of rockfish (Sebastes schlegeli) were investigated. The cytochrome P45O (CYP) contents and NADPH cytochrome P450 reductase, NADH cytochrome b5 reductase and 7-ethoxyredorufin-O-deethylase (EROD) activities of microsome, glutathione S-transferase (GST) activity of cytosol in rockfish exposed to 4-NP for 7 days using an intraperitoneal injection (25 mg/kg) were quantitatively determined. The GST activity of rockfish exposed to 4-NP were higher, up to 5.2 times higher, than those in the control fish. The activities of NADPH-and NADH-dependent reductases were inhibited. On the other hand, CYP contents and EROD activity of the 4-NP exposed fish demonstrated neither an increasing or decreasing trend.
ISSN
0374-8111
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/5413
Bibliographic Citation
한국수산과학회지, v.36, no.6, 2003
Publisher
한국수산과학회
Keywords
4-Nonylphenol; Sebastes schlegeli; Kidney; Cytochrome P450; EROD; Glutathione S-transferase
Type
Article
Publisher
한국수산과학회
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