노닐페놀을 주사한 조피볼락의 신장 MFO (mixed function oxidase)의 반응
KCI
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Title
- 노닐페놀을 주사한 조피볼락의 신장 MFO (mixed function oxidase)의 반응
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Alternative Title
- Responses of Renal Mixed Function Oxidase System in Rockfish (Sebastes schlegeli) Administered with 4-Nonylphenol
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Author(s)
- 전중균; 이지선; 손영창; 홍경표; 심원준; 김병기; 한창희
- KIOST Author(s)
- Shim, Won Joon(심원준)
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Alternative Author(s)
- 홍경표; 심원준
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Publication Year
- 2003-12
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Abstract
- Effects of 4-nonylphenol (4-NP) on mixed function oxygenase (MFO) in the kidneies of rockfish (Sebastes schlegeli) were investigated. The cytochrome P45O (CYP) contents and NADPH cytochrome P450 reductase, NADH cytochrome b5 reductase and 7-ethoxyredorufin-O-deethylase (EROD) activities of microsome, glutathione S-transferase (GST) activity of cytosol in rockfish exposed to 4-NP for 7 days using an intraperitoneal injection (25 mg/kg) were quantitatively determined. The GST activity of rockfish exposed to 4-NP were higher, up to 5.2 times higher, than those in the control fish. The activities of NADPH-and NADH-dependent reductases were inhibited. On the other hand, CYP contents and EROD activity of the 4-NP exposed fish demonstrated neither an increasing or decreasing trend.
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ISSN
- 0374-8111
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/5413
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Bibliographic Citation
- 한국수산과학회지, v.36, no.6, 2003
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Publisher
- 한국수산과학회
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Keywords
- 4-Nonylphenol; Sebastes schlegeli; Kidney; Cytochrome P450; EROD; Glutathione S-transferase
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Type
- Article
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