Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro SCIE SCOPUS

Cited 56 time in WEB OF SCIENCE Cited 0 time in Scopus
Title
Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro
Author(s)
Shim, JS; Lee, HS; Shin, J; Kwon, HJ
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2004-01-20
Abstract
Psammaplin A (PsA) is a phenolic natural product isolated from a marine sponge, which showed a potent cytotoxicity against several cancer cell lines. In present study, PsA was found to inhibit mammalian aminopeptidase N (APN) that plays a key role in tumor cell invasion and angiogenesis. PsA inhibited the APN activity with an IC50 of 18 muM in a non-competitive manner. Moreover, PsA potently inhibited the proliferation of several cancer and endothelial cells. Interestingly, the anti-proliferative effect of PsA was dependent on the cellular amount of APN expression. Finally, PsA suppressed the invasion and tube formation of endothelial cells stimulated by basic fibroblast growth factor. These data demonstrate that PsA is a new inhibitor of APN and can be developed as a novel anti-angiogenic agent. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
ISSN
0304-3835
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/5308
DOI
10.1016/j.canlet.2003.08.036
Bibliographic Citation
CANCER LETTERS, v.203, no.2, pp.163 - 169, 2004
Publisher
ELSEVIER IRELAND LTD
Subject
METHIONINE AMINOPEPTIDASE; TUMOR ANGIOGENESIS; GROWTH-FACTOR; CELLS; EXPRESSION; RECEPTOR; SPONGE; TARGET
Keywords
psammaplin A; aminopeptidase N; chemoinvasion; angiogenesis
Type
Article
Language
English
Document Type
Article
Publisher
ELSEVIER IRELAND LTD
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse