Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp KORDI-3238 SCIE SCOPUS

Cited 50 time in WEB OF SCIENCE Cited 58 time in Scopus
Title
Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp KORDI-3238
Author(s)
Jeong, Seong-Yun; Shin, Hee Jae; Kim, Tae Sik; Lee, Hyi-Seung; Park, Song-kyu; Kim, Hwan Mook
KIOST Author(s)
Shin, Hee Jae(신희재)Lee, Hyi Seung(이희승)
Publication Year
2006-04
Abstract
A new cytotoxic compound, streptokordin, and four known compounds, nonactic acid, dilactone, trilactone, and nonactin, were isolated from the fermentation broth of a marine actinomycete strain collected in deep-sea sediments. Biochemical tests and 16S rDNA analysis indicated that the strain belongs to the genus Streptomyces. This actinomycete produces various bioactive secondary metabolites. Fractionations by solvent partitioning, silica vacuum flash chromatography, and reversed-phase HPLC gave a pure cytotoxic compound, designated streptokordin. Its structure was elucidated by FAB-MS, H-1, C-13, and 2D NMR spectroscopy. Streptokordin exhibited significant cytotoxicity against seven human cancer cell lines but showed no growth inhibition against various microorganisms including bacteria and fungi.
ISSN
0021-8820
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4901
DOI
10.1038/ja.2006.33
Bibliographic Citation
JOURNAL OF ANTIBIOTICS, v.59, no.4, pp.234 - 240, 2006
Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
Keywords
Streptomyces sp KORDI-3238; 16S rDNA; cytotoxic; methylpyridine; 4-acetyl-6-methyl-1-H-pyridine-2-one
Type
Article
Language
English
Document Type
Article
Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse