Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp.
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Title
- Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp.
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Author(s)
- Jeong, Huijeong; Latif, Abdul; Kong, Chang-Suk; Seo, Youngwan; Lee, Yeon-Ju; Dalal, Seema R.; Cassera, Maria B.; Kingston, David G., I
- KIOST Author(s)
- Lee, Yeon Ju(이연주)
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Alternative Author(s)
- 이연주
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Publication Year
- 2019-11
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Abstract
- Six known compounds, namely two halisulfates 1 and 2 and four epidioxy sterols 3-6, were isolated from the marine sponge Coscinoderma sp. The structures of these compounds were confirmed by nuclear magnetic resonance (H-1 and C-13 NMR) spectroscopy, and their antiplasmodial activities were determined against the chloroquine-resistant Dd2 strain of Plasmodium falciparum. The epidioxy steroids 3-6 all showed moderate to weak antiplasmodial activity, with IC50 values of 2.7 mu M for (24S)-5 alpha,8 alpha-epidioxy-24-methylcholesta-6-en-3 beta-ol (3), 11.6 mu M for 5 alpha,8 alpha-epidioxycholesta-6,24(28)-dien-3 beta-o1 (4), 2.33 mu M for 5 alpha,8 alpha-epidioxy-24-methylcholesta-6,9(11)24(28)-trien-3 beta-ol (5), and between 12 and 24 mu M for 5 alpha,8 alpha-epidioxycholesta-6-en-3 beta-ol (6). In contrast, halisulfate 2 (1) was inactive, and halisulfate 1 (2) had an of IC50 value of about 24 mu M.
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ISSN
- 0939-5075
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/479
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DOI
- 10.1515/znc-2019-0039
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Bibliographic Citation
- ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, v.74, no.11-12, pp.313 - 318, 2019
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Publisher
- WALTER DE GRUYTER GMBH
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Subject
- STEROL
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Keywords
- antimalarial activity; Coscinoderma species; epidioxy sterols; halisulfates; purification
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Type
- Article
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Language
- English
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Document Type
- Article
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