Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp. SCIE SCOPUS

Cited 2 time in WEB OF SCIENCE Cited 2 time in Scopus
Title
Isolation and characterization of antiplasmodial constituents from the marine sponge Coscinoderma sp.
Author(s)
Jeong, Huijeong; Latif, Abdul; Kong, Chang-Suk; Seo, Youngwan; Lee, Yeon-Ju; Dalal, Seema R.; Cassera, Maria B.; Kingston, David G., I
KIOST Author(s)
Lee, Yeon Ju(이연주)
Publication Year
2019-11
Abstract
Six known compounds, namely two halisulfates 1 and 2 and four epidioxy sterols 3-6, were isolated from the marine sponge Coscinoderma sp. The structures of these compounds were confirmed by nuclear magnetic resonance (H-1 and C-13 NMR) spectroscopy, and their antiplasmodial activities were determined against the chloroquine-resistant Dd2 strain of Plasmodium falciparum. The epidioxy steroids 3-6 all showed moderate to weak antiplasmodial activity, with IC50 values of 2.7 mu M for (24S)-5 alpha,8 alpha-epidioxy-24-methylcholesta-6-en-3 beta-ol (3), 11.6 mu M for 5 alpha,8 alpha-epidioxycholesta-6,24(28)-dien-3 beta-o1 (4), 2.33 mu M for 5 alpha,8 alpha-epidioxy-24-methylcholesta-6,9(11)24(28)-trien-3 beta-ol (5), and between 12 and 24 mu M for 5 alpha,8 alpha-epidioxycholesta-6-en-3 beta-ol (6). In contrast, halisulfate 2 (1) was inactive, and halisulfate 1 (2) had an of IC50 value of about 24 mu M.
ISSN
0939-5075
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/479
DOI
10.1515/znc-2019-0039
Bibliographic Citation
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, v.74, no.11-12, pp.313 - 318, 2019
Publisher
WALTER DE GRUYTER GMBH
Subject
STEROL
Keywords
antimalarial activity; Coscinoderma species; epidioxy sterols; halisulfates; purification
Type
Article
Language
English
Document Type
Article
Publisher
WALTER DE GRUYTER GMBH
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse