Bithiazole metabolites from the myxobacterium Myxococcus fulvus SCIE SCOPUS

Cited 10 time in WEB OF SCIENCE Cited 11 time in Scopus
Title
Bithiazole metabolites from the myxobacterium Myxococcus fulvus
Author(s)
Ahn, Jong-Woong; Jang, Kyoung Hwa; Yang, Hyeong-Cheol; Oh, Ki-Bong; Lee, Hyi-Seung; Shin, Jongheon
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2007-03
Abstract
Two new bithiazole metabolites (3, 4) along with the previously reported compounds (1, 2) were isolated from the culture broth of the gliding bacterium Myxococcus fulvus collected from a Korean soil. The structures of these compounds were determined to be analogous to myxothiazole A on the basis of combined spectroscopic analyses. The new compounds exhibited significant cytotoxicity and moderate antifungal activity against the mouse fibloblast cell-line L929 and Candida albicans, respectively. These data were consistent with the previous finding that the bioactivity of myxothiazoles was highly dependent on the presence of terminal methoxy enol functionality.
ISSN
0009-2363
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4728
DOI
10.1248/cpb.55.477
Bibliographic Citation
CHEMICAL & PHARMACEUTICAL BULLETIN, v.55, no.3, pp.477 - 479, 2007
Publisher
PHARMACEUTICAL SOC JAPAN
Subject
CYSTOBACTER-FUSCUS; BIOLOGICAL-PROPERTIES; RESPIRATORY-CHAIN; MYXOTHIAZOL; ANTIBIOTICS; CYSTOTHIAZOLES; BIOSYNTHESIS
Keywords
myxobacterium; myxothiazole; antifungal activity; cytotoxicity
Type
Article
Language
English
Document Type
Article
Publisher
PHARMACEUTICAL SOC JAPAN
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