Bithiazole metabolites from the myxobacterium Myxococcus fulvus
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Title
- Bithiazole metabolites from the myxobacterium Myxococcus fulvus
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Author(s)
- Ahn, Jong-Woong; Jang, Kyoung Hwa; Yang, Hyeong-Cheol; Oh, Ki-Bong; Lee, Hyi-Seung; Shin, Jongheon
- KIOST Author(s)
- Lee, Hyi Seung(이희승)
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Alternative Author(s)
- 이희승
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Publication Year
- 2007-03
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Abstract
- Two new bithiazole metabolites (3, 4) along with the previously reported compounds (1, 2) were isolated from the culture broth of the gliding bacterium Myxococcus fulvus collected from a Korean soil. The structures of these compounds were determined to be analogous to myxothiazole A on the basis of combined spectroscopic analyses. The new compounds exhibited significant cytotoxicity and moderate antifungal activity against the mouse fibloblast cell-line L929 and Candida albicans, respectively. These data were consistent with the previous finding that the bioactivity of myxothiazoles was highly dependent on the presence of terminal methoxy enol functionality.
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ISSN
- 0009-2363
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/4728
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DOI
- 10.1248/cpb.55.477
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Bibliographic Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN, v.55, no.3, pp.477 - 479, 2007
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Publisher
- PHARMACEUTICAL SOC JAPAN
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Subject
- CYSTOBACTER-FUSCUS; BIOLOGICAL-PROPERTIES; RESPIRATORY-CHAIN; MYXOTHIAZOL; ANTIBIOTICS; CYSTOTHIAZOLES; BIOSYNTHESIS
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Keywords
- myxobacterium; myxothiazole; antifungal activity; cytotoxicity
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Type
- Article
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Language
- English
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Document Type
- Article
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