Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. SCIE SCOPUS
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, Hyi-Seung | - |
| dc.contributor.author | Lee, Tae-Hoon | - |
| dc.contributor.author | Yang, Seung Hwan | - |
| dc.contributor.author | Shin, Hee Jae | - |
| dc.contributor.author | Shin, Jongheon | - |
| dc.contributor.author | Oh, Ki-Bong | - |
| dc.date.accessioned | 2020-04-20T11:55:28Z | - |
| dc.date.available | 2020-04-20T11:55:28Z | - |
| dc.date.created | 2020-01-28 | - |
| dc.date.issued | 2007-05-01 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | https://sciwatch.kiost.ac.kr/handle/2020.kiost/4696 | - |
| dc.description.abstract | Two sesterterpene sulfates (1-2) were isolated from tropical sponge Hippospongia sp. and their inhibitory activities against isocitrate lyase (ICL) from the rice blast fungus Mgnaporthe grisea were evaluated. Compound 3 was obtained by hydrolysis of compound 1. Compounds I and 3 were found to be potent ICL inhibitors, which inhibited appressorium formation and C2 carbon utilization in M. grisea. Our results suggest that ICL plays crucial role in appressorium formation of M. grisea and is a new target for the protection of rice blast disease. (C) 2007 Elsevier Ltd. All rights reserved. | - |
| dc.description.uri | 1 | - |
| dc.language | English | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.subject | FUNGUS MAGNAPORTHE-GRISEA | - |
| dc.subject | RICE BLAST | - |
| dc.subject | GLYOXYLATE CYCLE | - |
| dc.subject | MYCOBACTERIUM-TUBERCULOSIS | - |
| dc.subject | PERSISTENCE | - |
| dc.subject | VIRULENCE | - |
| dc.subject | TURGOR | - |
| dc.subject | ENZYME | - |
| dc.title | Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. | - |
| dc.type | Article | - |
| dc.citation.endPage | 2486 | - |
| dc.citation.startPage | 2483 | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 17 | - |
| dc.citation.number | 9 | - |
| dc.contributor.alternativeName | 이희승 | - |
| dc.contributor.alternativeName | 신희재 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.9, pp.2483 - 2486 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2007.02.027 | - |
| dc.identifier.scopusid | 2-s2.0-33947726601 | - |
| dc.identifier.wosid | 000246087900018 | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.subject.keywordPlus | FUNGUS MAGNAPORTHE-GRISEA | - |
| dc.subject.keywordPlus | RICE BLAST | - |
| dc.subject.keywordPlus | GLYOXYLATE CYCLE | - |
| dc.subject.keywordPlus | MYCOBACTERIUM-TUBERCULOSIS | - |
| dc.subject.keywordPlus | PERSISTENCE | - |
| dc.subject.keywordPlus | VIRULENCE | - |
| dc.subject.keywordPlus | TURGOR | - |
| dc.subject.keywordPlus | ENZYME | - |
| dc.subject.keywordAuthor | sponge | - |
| dc.subject.keywordAuthor | Hippospongia sp | - |
| dc.subject.keywordAuthor | Mgnaporthe grisea | - |
| dc.subject.keywordAuthor | ICL inhibition | - |
| dc.subject.keywordAuthor | appressorium | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
- Appears in Collections:
- Marine Resources & Environment Research Division > Marine Biotechnology &Bioresource Research Department > 1. Journal Articles
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