Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. SCIE SCOPUS

Cited 36 time in WEB OF SCIENCE Cited 38 time in Scopus
Title
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
Author(s)
Lee, Hyi-Seung; Lee, Tae-Hoon; Yang, Seung Hwan; Shin, Hee Jae; Shin, Jongheon; Oh, Ki-Bong
KIOST Author(s)
Lee, Hyi Seung(이희승)Shin, Hee Jae(신희재)
Publication Year
2007-05-01
Abstract
Two sesterterpene sulfates (1-2) were isolated from tropical sponge Hippospongia sp. and their inhibitory activities against isocitrate lyase (ICL) from the rice blast fungus Mgnaporthe grisea were evaluated. Compound 3 was obtained by hydrolysis of compound 1. Compounds I and 3 were found to be potent ICL inhibitors, which inhibited appressorium formation and C2 carbon utilization in M. grisea. Our results suggest that ICL plays crucial role in appressorium formation of M. grisea and is a new target for the protection of rice blast disease. (C) 2007 Elsevier Ltd. All rights reserved.
ISSN
0960-894X
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4696
DOI
10.1016/j.bmcl.2007.02.027
Bibliographic Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.9, pp.2483 - 2486, 2007
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Subject
FUNGUS MAGNAPORTHE-GRISEA; RICE BLAST; GLYOXYLATE CYCLE; MYCOBACTERIUM-TUBERCULOSIS; PERSISTENCE; VIRULENCE; TURGOR; ENZYME
Keywords
sponge; Hippospongia sp; Mgnaporthe grisea; ICL inhibition; appressorium
Type
Article
Language
English
Document Type
Article
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
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