Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. SCIE SCOPUS
Cited 36 time in
WEB OF SCIENCE
Cited 38 time in
Scopus
- Title
- Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
- KIOST Author(s)
- Lee, Hyi Seung(이희승); Shin, Hee Jae(신희재)
- Alternative Author(s)
- 이희승; 신희재
- Publication Year
- 2007-05-01
- Abstract
- Two sesterterpene sulfates (1-2) were isolated from tropical sponge Hippospongia sp. and their inhibitory activities against isocitrate lyase (ICL) from the rice blast fungus Mgnaporthe grisea were evaluated. Compound 3 was obtained by hydrolysis of compound 1. Compounds I and 3 were found to be potent ICL inhibitors, which inhibited appressorium formation and C2 carbon utilization in M. grisea. Our results suggest that ICL plays crucial role in appressorium formation of M. grisea and is a new target for the protection of rice blast disease. (C) 2007 Elsevier Ltd. All rights reserved.
- ISSN
- 0960-894X
- Bibliographic Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.9, pp.2483 - 2486, 2007
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Subject
- FUNGUS MAGNAPORTHE-GRISEA; RICE BLAST; GLYOXYLATE CYCLE; MYCOBACTERIUM-TUBERCULOSIS; PERSISTENCE; VIRULENCE; TURGOR; ENZYME
- Keywords
- sponge; Hippospongia sp; Mgnaporthe grisea; ICL inhibition; appressorium
- Type
- Article
- Language
- English
- Document Type
- Article
- Files in This Item:
- There are no files associated with this item.
