Protective effect of enzymatic extracts from microalgae against DNA damage induced by H2O2 SCIE SCOPUS

Cited 23 time in WEB OF SCIENCE Cited 30 time in Scopus
Title
Protective effect of enzymatic extracts from microalgae against DNA damage induced by H2O2
Author(s)
Karawita, Rohan; Senevirathne, Mahinda; Athukorala, Yasantha; Affan, Abu; Lee, Young-Jae; Kim, Se-Kwon; Lee, Joon-Baek; Jeon, You-Jin
Publication Year
2007-08
Abstract
The enzymatic extracts from seven species of microalgae (Pediastrum duplex, Dactylococcopsis fascicularis, Halochlorococcum porphyrae, Oltmannsiellopsis unicellularis, Achnanthes longipes, Navicula sp. and Amphora coffeaeformis) collected from three habitats (freshwater, tidal pool, and coastal benthic) at Jeju Island in Korea were investigated for their antioxidant activity. Of the extracts tested, the AMG 300 L (an exo 1, 4-alpha-D-glucosidase) extract of P. duplex, the Viscozyme extract of Navicula sp., and the Celluclast extract of A. longipes provided the most potential as antioxidants. Meanwhile, the Termamyl extract of P. duplex in an H2O2 scavenging assay exhibited an approximate 60% scavenging effect. In this study, we report that the DNA damage inhibitory effects of P. duplex (Termamyl extract) and D. fascicularis (Kojizyme extract) were nearly 80% and 69% respectively at a concentration of 100 mu g/ml. Thus, it is suggested that the microalgae tested in this study yield promising DNA damage inhibitory properties on mouse lymphoma L 5178 cells that are treated with H2O2. Therefore, microalgae such as P. duplex may be an excellent source of naturally occurring antioxidant compounds with potent DNA damage inhibition potential.
ISSN
1436-2228
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4661
DOI
10.1007/s10126-007-9007-3
Bibliographic Citation
MARINE BIOTECHNOLOGY, v.9, no.4, pp.479 - 490, 2007
Publisher
SPRINGER
Subject
ANTIOXIDANT PROPERTIES; HUMAN-LYMPHOCYTES; STRAND BREAKS; CELL-DEATH; ASSAY; ALGA; CAROTENOIDS; MECHANISMS; CULTURE; VIVO
Keywords
antioxidant activity; DNA damage; enzymatic extracts; H2O2; microalgae; scavenging activity
Type
Article
Language
English
Document Type
Article
Publisher
SPRINGER
Files in This Item:
There are no files associated with this item.

qrcode

Items in ScienceWatch@KIOST are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse