Inhibition of the pathogenicity of Magnaporthe grisea by bromophenols, isocitrate lyase inhibitors, from the red alga Odonthalia corymbifera SCIE SCOPUS

Cited 55 time in WEB OF SCIENCE Cited 57 time in Scopus
Title
Inhibition of the pathogenicity of Magnaporthe grisea by bromophenols, isocitrate lyase inhibitors, from the red alga Odonthalia corymbifera
Author(s)
Lee, Hyi-Seung; Lee, Tae-Hoon; Lee, Ji Hye; Chae, Choong-Sik; Chung, Soon-Chun; Shin, Dong-Sun; Shin, Jongheon; Oho, Ki-Bong
KIOST Author(s)
Lee, Hyi Seung(이희승)
Publication Year
2007-08-22
Abstract
Magnaporthe grisea is a fungal pathogen of rice that forms appressoria that penetrate the outer cuticle of the rice plant. Data from recent studies indicate that M. grisea isocitrate lyase (ICL), a key enzyme in the glyoxylate cycle, is highly expressed during appressorium-mediated plant infection. Bromophenols isolated from the red alga Odonthalia corymbifera exhibited potent ICL inhibitory activity and blocked appressoria formation by M. grisea in a concentration-dependent manner. In addition, these compounds protected the rice plants from infection by M. grisea. Rice plants infected with wild-type M. grisea Guy 11 exhibited significantly lower disease severity with bromophenol treatment than without, and the treatment effect was comparable to the behavior of the Delta icl knockout mutant I-10. The protective effect of bromophenols and their strong inhibition of appressorium formation on rice plants suggest that ICL inhibitors may be promising candidates for crop protection, particularly to protect rice plants against M. grisea.
ISSN
0021-8561
URI
https://sciwatch.kiost.ac.kr/handle/2020.kiost/4648
DOI
10.1021/jf071125r
Bibliographic Citation
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.55, no.17, pp.6923 - 6928, 2007
Publisher
AMER CHEMICAL SOC
Subject
RHODOMELA-CONFERVOIDES; RICE-BLAST; MYCOBACTERIUM-TUBERCULOSIS; GLYOXYLATE CYCLE; SYMPHYOCLADIA-LATIUSCULA; MALATE SYNTHASE; VIRULENCE; REQUIRES; PENETRATION; DERIVATIVES
Keywords
Magnaporthe grisea; appressoria; infection; rice; disease symptom; isocitrate lyase inhibitor; Odonthalia corymbifera; bromophenols
Type
Article
Language
English
Document Type
Article
Publisher
AMER CHEMICAL SOC
Related Researcher
Research Interests

Marine Natural Products,Organic Chemistry,해양천연물,유기화학

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