Labdane-Type Diterpenoids from Streptomyces griseorubens and Their Antimicrobial and Cytotoxic Activities
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Title
- Labdane-Type Diterpenoids from Streptomyces griseorubens and Their Antimicrobial and Cytotoxic Activities
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Author(s)
- Heo, Chang Su; Kang, Jong Soon; Yang, Jeong-Wook; Lee, Min Ah; Lee, Hwa Sun; Shin, Hee Jae
- KIOST Author(s)
- Heo, Chang Su(허창수); Lee, Min Ah(이민아); Lee, Hwa Sun(이화선); Shin, Hee Jae(신희재)
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Alternative Author(s)
- 허창수; 이민아; 이화선; 신희재
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Publication Year
- 2024-03
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Abstract
- Chemical investigation of the ethyl acetate (EtOAc) extract from a marine-derived actinomycete, Streptomyces griseorubens, resulted in the discovery of five new labdane-type diterpenoids: chlorolabdans A-C (1–3), epoxylabdans A and B (4 and 5), along with one known analog (6). The structures of the new compounds were determined by spectroscopic analysis (HR-ESIMS, 1D, and 2D NMR) and by comparing their experimental data with those in the literature. The new compounds were evaluated for their antimicrobial activity, and 2 displayed significant activity against Gram-positive bacteria, with minimum inhibitory concentration (MIC) values ranging from 4 to 8 µg/mL. Additionally, 1, 2, and 4 were tested for their cytotoxicity against seven blood cancer cell lines by CellTiter-Glo (CTG) assay and six solid cancer cell lines by sulforhodamine B (SRB) assay; 1, 2, and 4 exhibited cytotoxic activities against some blood cancer cell lines, with concentration causing 50% cell growth inhibition (IC50) values ranging from 1.2 to 22.5 µM.
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ISSN
- 1661-6596
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/45434
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DOI
- 10.3390/ijms25063311
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Bibliographic Citation
- International Journal of Molecular Sciences, v.25, no.6, 2024
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Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
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Keywords
- Streptomyces griseorubens; labdane; diterpenoids; antimicrobial; cytotoxicity; chlorolabdan; epoxylabdan
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Type
- Article
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Language
- English
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