Meirols A–C: Bioactive Catecholic Compounds from the Marine-Derived Fungus Meira sp. 1210CH-42
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Title
- Meirols A–C: Bioactive Catecholic Compounds from the Marine-Derived Fungus Meira sp. 1210CH-42
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Author(s)
- Lee, Min Ah; Kang, Jong Soon; Yang, Jeong-Wook; Lee, Hwa Sun; Heo, Chang Su; Park, Sun Joo; Shin, Hee Jae
- KIOST Author(s)
- Lee, Min Ah(이민아); Lee, Hwa Sun(이화선); Heo, Chang Su(허창수); Shin, Hee Jae(신희재)
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Alternative Author(s)
- 이민아; 이화선; 허창수; 신희재
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Publication Year
- 2024-02
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Abstract
- Three new catecholic compounds, named meirols A–C (2–4), and one known analog, argovin (1), were isolated from the marine-derived fungus Meira sp. 1210CH-42. Their structures were determined by extensive analysis of 1D, 2D NMR, and HR-ESIMS spectroscopic data. Their absolute configurations were elucidated based on ECD calculations. All the compounds exhibited strong antioxidant capabilities with EC50 values ranging from 6.01 to 7.47 μM (ascorbic acid, EC50 = 7.81 μM), as demonstrated by DPPH radical scavenging activity assays. In the α-glucosidase inhibition assay, 1 and 2 showed potent in vitro inhibitory activity with IC50 values of 184.50 and 199.70 μM, respectively (acarbose, IC50 = 301.93 μM). Although none of the isolated compounds exhibited cytotoxicity against one normal and six solid cancer cell lines, 1 exhibited moderate cytotoxicity against the NALM6 and RPMI-8402 blood cancer cell lines with GI50 values of 9.48 and 21.00 μM, respectively. Compound 2 also demonstrated weak cytotoxicity against the NALM6 blood cancer cell line with a GI50 value of 29.40 μM.
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ISSN
- 1660-3397
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URI
- https://sciwatch.kiost.ac.kr/handle/2020.kiost/45401
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DOI
- 10.3390/md22020087
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Bibliographic Citation
- Marine Drugs, v.22, no.2, 2024
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Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
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Keywords
- marine fungus; natural product; Meira sp.; indanone; catechol; meirol; DPPH radical scavenging; α-glucosidase inhibitor; cytotoxicity
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Type
- Article
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Language
- English
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